Natural killer cell cytotoxicity panel - Blood mononuclear cells 82720-4
LOINC Code
| LOINC code | 82720-4 | ||
|---|---|---|---|
| name | Natural killer cell cytotoxicity panel - Blood mononuclear cells | ||
| description | The natural killer (NK) cytotoxicity profile assesses the functionality of natural killer cells and is used to evaluate patients with various conditions, including recurrent herpes viral infections, hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects. The NK cytotoxicity profile is also used for the evaluation of immune reconstitution post hematopoietic cell transplantation and post immunomodulatory therapy. Peripheral blood mononuclear cells (PBMCs) are used as the specimen for NK cytotoxicity assays because the cytotoxicity of the MC population is predominantly due to NK cells. In the cytotoxicity assay, samples of the patient's mononuclear cells (called 'effector cells' or E cells') are incubated with labeled target cells ('T cells') in a series of predetermined ratios, for example, 100:1 E to T, 50:1 E to T, 25:1 E to T. Cytotoxicity is measured as the amount of label released when the target cell is destroyed, and the percent cytotoxicity for a given E:T ratio is the ratio of label released when all of the target cells are destroyed using a cell lysis detergent as an experimental control. Several features of the cytotoxicity profile are important, including the maximum cytotoxicity, the relative difference between the maximum and the minimum, and the change in percent cytotoxicity between sequential dilutions. Different patterns of these measures may be associated with different disease processes. Cytotoxicity may also be reported in terms of lytic units [LOINC: 34439-0], meaning the number of E cells needed to lyse a certain number of target cells. | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | Natural killer cell cytotoxicity panel | ||
| property | - | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | Bld MC Bld = Whole blood | ||
| scale | - | ||
| method | |||
Additional Names | |||
| short name | NK cytotox Pnl Bld MC | ||
Basic Attributes | |||
| class | PANEL.HEM/BC | ||
| type | 1 Laboratory | ||
| order vs. observation | Order | ||
Panel Components | |||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
History/Usage | |||
| first released | |||
| last updated | 2.64 | ||
| last change type | MIN - change to field other than name | ||
Related Names | |||
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