t(9;22)(q34.1;q11)(ABL1,BCR) fusion transcript/control transcript [Log Number Ratio] in Bone marrow by Molecular genetics method 82905-1
LOINC Code
| LOINC code | 82905-1 | ||
|---|---|---|---|
| name | t(9;22)(q34.1;q11)(ABL1,BCR) fusion transcript/control transcript [Log Number Ratio] in Bone marrow by Molecular genetics method | ||
| description | The level of fusion gene transcript in the test sample is expressed as a log reduction; i.e., log10 of the ratio of chimeric BCR-ABL/normal ABL mRNA transcript seen in individuals with untreated CML (Chronic Myelogenous Leukemia) as compared to the ratio seen in the patient. In Quest's laboratory data, the median of BCR-ABL/ABL Ratio in previously untreated CML patients is 4.1325 in peripheral blood samples (N=120) and 5.09 in bone marrow samples (N=109). Based on the IRIS study (New England Journal of Medicine, 2003, 3349:1423-1432), it is not necessary to know the BCR-ABL:ABL ratio of a patient at baseline to calculate the subsequent change and this calculation should be based on the above-mentioned median. Based on this study, a 3 log of higher reduction by 12 months of therapy is associated with negligible risk of disease progression during the subsequent 12 months with patients are treated with imatinib. The following formula is used for calculating log reduction by Quest Laboratories: LOG10(4.1325)-LOG10 (BCR-ABL:ABL ratio) Unit/Log Reduction. Information from Quest Diagnostics. 2006 12 06. | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | t(9;22)(q34.1;q11)(ABL1,BCR) fusion transcript/control transcript | ||
| property | LnRto = Log Number Ratio | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | Bone mar = Marrow (bone) | ||
| scale | Qn = Quantitative: The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256 | ||
| method | Molgen = Molecular Genetics: General class of methods used to detect genetic attributes on a molecular basis including RFL, PCR and other methods. | ||
Additional Names | |||
| short name | t(9;22)(ABL1,BCR)/control Mar-LnRto | ||
Basic Attributes | |||
| class | MOLPATH.TRNLOC | ||
| type | 1 Laboratory | ||
| order vs. observation | Both | ||
| example UCUM units | {log_reduction} The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org) | ||
| example unit | Log Reduction | ||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
History/Usage | |||
| first released | |||
| last updated | 2.58 | ||
| last change type | ADD - added | ||
Related Names | |||
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Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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