AHA Coding Clinic® for ICD-10-CM and ICD-10-PCS - 2021 Issue 4; ICD-10-CM New/Revised Codes

Abnormal Findings of Blood Amino-Acid Level

A new code was created to describe abnormal findings of blood amino-acid level (R79.83), which includes homocysteinemia. Previously, ICD-10-CM classified homocysteinemia and homocystinuria to code E72.11, Homocystinuria, within subcategory E72.1, Disorders of sulfur-bearing amino-acid metabolism. However, clinically, homocysteinemia is distinct from homocystinuria, as homocystinuria generally refers to an inborn error of metabolism, and typically manifests with certain phenotypes representing disease states. Homocysteinemia is defined as elevation of homocysteine levels in blood. Therefore, using the term homocysteinemia in the clinical setting does not express the same meaning as homocystinuria. ...

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