BC Advantage - 2020 Issue 10

New Codes for Cytokine Release Syndrome (CRS)

Cytokine release syndrome (CRS), sometimes referred to as a cytokine storm, is a systemic inflammatory response triggered by a variety of reasons such as infections, certain drugs, or after treatment with some types of immunotherapy, (e.g., monoclonal antibodies and CAR-T cells).  It is characterized by a large, rapid release of cytokines into the blood. Cytokines are small proteins that help cells around the body communicate. When the immune system detects a threat, cells release cytokines to coordinate the body's response. Too many cytokines cause harmful levels of inflammation throughout the body. Symptoms of CRS may include nausea...

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