KC22.2 Sclerema neonatorum

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01

Sclerema neonatorum is an uncommon condition which typically affects gravely ill, preterm neonates in the first week of life. It manifests as a diffuse hardening of skin and subcutaneous adipose tissue such that the skin cannot be pitted or picked up and pinched into a fold. Histologically there is minimal inflammation without fat necrosis. It is associated with a high mortality.

synonyms

• Sclerema neonatorum
• newborn scleroderma
• Underwood's disease

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