5A60.3 Central precocious puberty
International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01
Central precocious puberty is defined as the onset of pubertal changes before 8 years of age in girls and before 9.5 years of age in boys due to the overproduction of gonadotropin-releasing hormone (GnRH) by the hypothalamus. It may be idiopathic with no apparent cause (90% of cases in girls, 50% of cases in boys) or secondary to a lesion (tumour or malformation) in the hypothalamus. Other causes may include traumatic brain injury, or genetic disorders, affecting behavioural and psychological development, and final body height.
synonyms
- Central precocious puberty
- Gonadotropin-dependant precocious puberty
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