DB99.5 Hepatic encephalopathy International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2026-01 Hepatic encephalopathy is a complication of liver cirrhosis and a hallmark of acute liver failure, and is also observed in patients with portosystemic shunts without cirrhosis. Hepatic encephalopathy is characterised by personality changes, intellectual impairment, flapping tremor and a decreased consciousness level. In the advanced stages it is called hepatic coma, which may lead to death. The diagnosis of hepatic encephalopathy is made primarily by recognition of neuropsychiatric changes occurring in a patient with liver disease, after exclusion of brain diseases.
exclusions postcoordination Add Stem and/or Extension codes to form a cluster code which adds detail to the condition.
Has severity - only one may be selected [select] XS8H None XS5W Mild XS0T Moderate XS25 Severe XS2R Profound XS7A Stage 1 XS5S Stage 2 XS4D Stage 2a XS6D Stage 2b XS00 Stage 3 XS3T Stage 3a XS90 Stage 3b XS6G Stage 4 XS9N Stage 5 XS88 Stage 6 XS52 Stage 7 XS0G Stage 8 XS2C Stage 9 XS2X Stage 10 XS24 Grade 0 XS6P Grade 1 XS31 Grade 2 XS6F Grade 3 XS0K Grade 4 XS87 Grade 5 XS9M Grade 6 XS5M Grade 7 XS7F Grade 8 XS8J Grade 9 XS57 Grade 10 XS4A Phase 0 XS3K Phase 1 XS4M Phase 2 XS8V Phase 3 XS21 Phase 4 XS8Z Phase 5 XS41 Phase 6 XS73 Phase 7 XS9Z Phase 8 XS83 Phase 9 XS47 Phase 10 XS5C 0 No problem XS6Y 1 Mild problem XS8T 2 Moderate problem XS9D 3 Severe problem XS91 4 Complete problem XS5P 9 Not applicable XS0X End stage XS8N Advanced XS0J A Remission / Free of disease XS05 B Local Disease XS9S C Regional disease XS4Z D Distant disease XS76 Stage 0 XS1G Stage I XS4P Stage II XS6H Stage III XS9R Stage IV XS56 Grade I XS58 Grade II XS7Z Grade III XS7M Grade IV XS7H Undetermined grade XS3A NYHA Class I - No limitation of physical activity XS6B NYHA Class II - Slight limitation of physical activity XS9T NYHA Class III - Marked limitation of physical activity XS9F NYHA Class IV - Unable to carry on any physical activity without discomfort XS80 GOLD 1 - mild: FEV1≥ 80% predicted XS7U GOLD 2 - moderate: 50% ≤FEV1 <80% predicted XS8K GOLD 3 - severe: 30% ≤FEV1 <50% predicted XS50 GOLD 4 - very severe: FEV1 <30% predicted XS1Y Stage I: Asymptomatic, incomplete blood vessel obstruction XS5L Stage II: Mild claudication pain in limb XS9L Stage III: Rest pain, mostly in the feet XS2J Stage IV: Necrosis and/or gangrene of the limb XS3V No endometriosis XS5N Filmy endometriosis XS55 Dense endometriosis XS1H Incomplete vocal cord paralysis XS66 Partial vocal cord paralysis XS7K Complete vocal cord paralysis XS5E Mild sepsis XS65 Severe sepsis XS26 Septic shock XS1T Grade 0 Category 0: Asymptomatic -no hemodynamically significant occlusive disease XS0Q Grade 0 Category 1: Mild claudication XS2W Grade I Category 2: Moderate claudication XS51 Grade I Category 3: Severe claudication XS8M Grade II Category 4: Ischaemic rest pain XS6U Grade III Category 5: Minor tissue loss - nonhealing ulcer, focal gangrene with diffuse pedal ischaemia XS0U Grade III Category 6: Major tissue loss - extending above transmetatarsal (TM) level, functional foot no longer salvageable XS7G Psychosocial factors present XS8B No psychosocial factors present XS11 Underweight BMI Below 18.5 kg/m² XS43 Normal weight BMI 18.5–24.9 kg/m² XS7R Pre-obesity BMI 25.0–29.9 kg/m² XS3Y Obesity class I BMI 30.0–34.9 kg/m² XS6N Obesity class II BMI 35.0–39.9 kg/m² XS2B Obesity class III BMI greater than or equal to 40 kg/m² XS2V Single vessel disease XS8U Multiple vessel disease XS09 Anaphylaxis grade 1 XS59 Anaphylaxis grade 2 XS2Y Anaphylaxis grade 3 XS85 Anaphylaxis grade 4 XS0E Local limited XS67 Locally advanced XS5V Stage IIA: Claudication at a distance > 200 metres XS6C Stage IIB: Claudication at a distance < 200 metres XS5B No pain XS5D Mild pain XS9Q Moderate pain XS2E Severe pain XS1J No distress XS3R Mild distress XS7C Moderate distress XS7N Severe distress XS71 No pain-related interference XS5R Mild pain-related interference XS2L Moderate pain-related interference XS2U Severe pain-related interference Course - only one may be selected [select] XT5R Acute XT8W Chronic Has causing condition - a selection is required - multiple selections are allowed [select] 1E50 Acute viral hepatitis 1E51 Chronic viral hepatitis 1E5Z Viral hepatitis, unspecified 1E50.0 Acute hepatitis A 1E50.1 Acute hepatitis B 1E50.2 Acute hepatitis C 1E50.3 Acute hepatitis D 1E50.4 Acute hepatitis E 1E50.Y Other specified acute viral hepatitis 1E50.Z Acute viral hepatitis, unspecified 1E51.0 Chronic hepatitis B 1E51.1 Chronic hepatitis C 1E51.2 Chronic hepatitis D 1E51.3 Chronic hepatitis E 1E51.Y Other specified chronic viral hepatitis 1E51.Z Chronic viral hepatitis, unspecified 1E51.00 Chronic hepatitis B with human immunodeficiency virus co-infection 1E51.0Y Other specified chronic hepatitis B 1E51.0Z Chronic hepatitis B, unspecified 5C90 Metabolic or transporter liver disease 5C90.0 Liver diseases due to urea cycle defects 5C90.1 Liver diseases due to disorders of porphyrin or bilirubin metabolism or transport 5C90.2 Liver diseases due to disorders of amino acid metabolism 5C90.3 Liver disease due to disorders of lysosomal storage 5C90.4 Liver diseases due to mitochondrial disorders 5C90.5 Liver diseases due to disorders of mineral metabolism 5C90.Y Other specified metabolic or transporter liver disease 5C90.Z Metabolic or transporter liver disease, unspecified BC43.Y Other specified cardiomyopathy DB90 Infectious liver disease DB90.0 Abscess of liver DB90.Y Other specified infectious liver disease DB90.Z Infectious liver disease, unspecified DB91 Acute or subacute hepatic failure DB91.0 Acute or subacute hepatic failure due to hepatitis virus DB91.1 Other acute or subacute hepatic failure DB91.Z Acute or subacute hepatic failure, unspecified DB92 Non-alcoholic fatty liver disease DB92.0 Non-alcoholic fatty liver disease without non-alcoholic steatohepatitis DB92.1 Non-alcoholic steatohepatitis DB92.Y Other specified non-alcoholic fatty liver disease DB92.Z Non-alcoholic fatty liver disease, unspecified DB93 Hepatic fibrosis or cirrhosis DB93.0 Hepatic fibrosis DB93.1 Hepatic cirrhosis DB93.2 Certain specified fibrosis or cirrhosis of liver DB93.Y Other specified hepatic fibrosis or cirrhosis DB93.20 Hereditary North American Indian childhood cirrhosis DB93.21 Idiopathic copper-associated cirrhosis DB94 Alcoholic liver disease DB94.0 Alcoholic fatty liver DB94.1 Alcoholic hepatitis DB94.2 Alcoholic liver fibrosis DB94.3 Alcoholic cirrhosis of liver without hepatitis DB94.Y Other specified alcoholic liver disease DB94.Z Alcoholic liver disease, unspecified DB94.10 Alcoholic hepatitis with cirrhosis DB94.1Y Other specified alcoholic hepatitis DB94.1Z Alcoholic hepatitis, unspecified DB95 Drug-induced or toxic liver disease DB95.0 Drug-induced or toxic liver disease with acute hepatic necrosis or acute hepatitis DB95.1 Drug-induced or toxic liver disease with chronic hepatitis DB95.2 Drug-induced or toxic liver disease with cholestasis DB95.3 Drug-induced or toxic liver disease with fatty liver DB95.4 Drug-induced or toxic liver disease with granulomatous hepatitis DB95.5 Drug-induced or toxic liver disease with fibrosis or cirrhosis of liver DB95.6 Drug-induced or toxic liver disease with vascular disorders of the liver DB95.7 Drug-induced or toxic liver disease with liver tumours DB95.Y Other specified drug-induced or toxic liver disease DB95.Z Drug-induced or toxic liver disease, unspecified DB95.10 Drug-induced or toxic liver disease with chronic hepatitis with cirrhosis DB95.11 Drug-induced or toxic liver disease with chronic hepatitis without cirrhosis DB95.1Z Drug-induced or toxic liver disease with chronic hepatitis, unspecified DB95.20 Chronic drug-induced or toxic liver disease with cholestasis DB95.2Y Other specified drug-induced or toxic liver disease with cholestasis DB95.2Z Drug-induced or toxic liver disease with cholestasis, unspecified DB95.30 Drug-induced or toxic liver disease with chronic fatty liver disease DB95.3Y Other specified drug-induced or toxic liver disease with fatty liver DB95.3Z Drug-induced or toxic liver disease with fatty liver, unspecified DB96 Autoimmune liver disease DB96.0 Autoimmune hepatitis DB96.1 Primary biliary cholangitis DB96.2 Primary sclerosing cholangitis DB96.Y Other specified autoimmune liver disease DB96.Z Autoimmune liver disease, unspecified DB96.10 Primary biliary cholangitis with overlap syndrome DB96.1Y Other specified primary biliary cholangitis DB96.1Z Primary biliary cholangitis, unspecified DB96.20 Primary sclerosing cholangitis with cirrhosis DB96.2Y Other specified primary sclerosing cholangitis DB96.2Z Primary sclerosing cholangitis, unspecified DB97 Certain specified inflammatory liver diseases DB97.0 Idiopathic granulomatous hepatitis DB97.1 Hepatic berylliosis DB97.2 Chronic hepatitis, not elsewhere classified DB97.Y Other specified inflammatory liver disease DB97.Z Inflammatory liver disease, unspecified DB98 Vascular disorders of the liver DB98.0 Infarction of liver DB98.1 Peliosis hepatis DB98.2 Nodular regenerative hyperplasia of liver DB98.3 Portal vein thrombosis DB98.4 Splenic vein thrombosis DB98.5 Budd-Chiari syndrome DB98.6 Hepatic veno-occlusive disease DB98.7 Portal hypertension DB98.8 Passive congestion of liver DB98.9 Hepatic artery aneurysm DB98.A Hepatic haemorrhage DB98.B Ischaemia reperfusion injury of liver DB98.Y Other specified vascular disorders of the liver DB98.Z Vascular disorders of the liver, unspecified DB98.70 Idiopathic portal hypertension DB98.71 Non-cirrhotic portal fibrosis DB98.72 Partial nodular transformation of liver DB98.73 Splanchnic arteriovenous fistula DB98.74 Secondary portal hypertension DB98.7Y Other specified portal hypertension DB98.7Z Portal hypertension, unspecified DB99.0 Chronic liver disease DB99.1 Hepatic cyst DB99.10 Polycystic liver disease DB99.1Y Other specified hepatic cyst DB99.1Z Hepatic cyst, unspecified DB99.2 Hepatorenal syndrome DB99.3 Portopulmonary hypertension DB99.4 Hepatopulmonary syndrome DB99.Y Other specified diseases of liver DB99.6 Intrahepatic cholestasis, not elsewhere classified DB99.60 Cholestasis of parenteral nutrition DB99.6Y Other specified intrahepatic cholestasis DB99.6Z Intrahepatic cholestasis, unspecified DB99.7 Hepatic failure without mention whether acute or chronic DB99.8 Chronic hepatic failure DB9Z Diseases of liver, unspecified JA65.0 Liver disorders in pregnancy, childbirth or the puerperium LA90.21 Congenital portosystemic shunt LB20.0 Structural developmental anomalies of liver LB20.00 Fibropolycystic liver disease LB20.0Y Other specified structural developmental anomalies of liver LB20.0Z Structural developmental anomalies of liver, unspecified
synonyms Hepatic encephalopathy HE - [hepatic encephalopathy] hepatic encephalopathy NOS hepatic encephalopathy, stage unspecified hepatocerebral encephalopathy hepatocerebral intoxication metabolic hepatic encephalopathy portal-systemic encephalopathy portosystemic encephalopathy Hepatic encephalopathy, stage 1 Hepatic encephalopathy, stage 2 Hepatic encephalopathy, stage 3 Hepatic encephalopathy, stage 4 Acute hepatic encephalopathy acute hepatoencephalopathy Acute hepatorenal encephalopathy acute hepatorenal coma Acute portosystemic encephalopathy Gaustad's syndrome Transient hepatargy syndrome Hepatic encephalopathy, minimal Covert hepatic encephalopathy MHE - [Minimal hepatic encephalopathy] Hepatic coma
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