3A20.1 Autoimmune haemolytic anaemia, cold type

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2026-01

Cold autoimmune haemolytic anaemia comprises two types of autoimmune haemolytic anaemia (AIHA) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C): cold agglutinin disease (CAD), which is the more common, and paroxysmal cold haemoglobinuria (PCH). CAD is more common in people over the age of 55 years, while PCH typically presents in young children. CAD is caused by IgM autoantibodies while PCH is caused by an IgG immunoglobulin.

inclusions

• Cold haemagglutinin disease

exclusions

• Immune thrombocytopenic purpura  (3B64.10)
• Haemolytic disease of fetus or newborn  (KA84)

synonyms

• Autoimmune haemolytic anaemia, cold type
• autoimmune cold sense
• autoimmune cold sensitivity
• autoimmune haemolytic anaemia due to cold antibodies
• cold antibody haemolytic anaemia
• cold autoimmune haemolytic anaemia
• cold haemolytic disease
• cryopathic haemolytic anaemia
• idiopathic cold autoimmune haemolytic anaemia
• secondary cold type haemolytic anaemia
• symptomatic cold type haemolytic anaemia
• Cold haemagglutinin disease
• CHAD - [cold hemagglutinin disease]
• Cold agglutinin disease
• Cold agglutinin haemoglobinuria
• cold agglutinin disease or haemoglobinuria
• cold hemagglutinin disease

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