ICD-11 MMS

01 Certain infectious or parasitic diseases

Viral infections characterised by skin or mucous membrane lesions  (1E70-1F0Z)

1F00 Herpes simplex infections

1F00.2 Herpes simplex infection of central nervous system

1F00.21 Encephalitis due to herpes simplex virus

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01


Herpetic encephalitis is a cerebral infection caused by herpes simplex virus type 1 (HSV1). It presents as acute necrosing temporal encephalitis. Onset is rapid (less than 48 hours) with a fever of 40 °C, headaches, and behavioural, language and memory problems. These initial manifestations are followed by numbness and coma, which may be accompanied by convulsions and paralysis. This disease, which affects only a small minority of HSV1-infected individuals, results from a primary immune deficiency.

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