5A70.0 Pituitary-dependent Cushing disease

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01

Pituitary-dependent Cushing disease is caused by a pituitary tumour, generally benign (adenoma) but rarely malignant (carcinoma), which secretes adrenocorticotropin (ACTH) autonomously, leading to hypercortisolism. The condition is associated with increased morbidity and mortality that can be mitigated by treatments that result in sustained endocrine remission. Transsphenoidal pituitary surgery (TSS) remains the mainstay of treatment for this disease but requires considerable neurosurgical expertise and experience in order to optimize patient outcomes.

synonyms

• Pituitary-dependent Cushing disease
• Overproduction of pituitary ACTH
• Pituitary-dependent hyperadrenocorticism
• Corticotroph pituitary adenoma
• ACTH- [adrenocorticotropic hormone] secreting pituitary adenoma
• Cushing syndrome or disease, pituitary-dependent
• Cushings basophilism
• Cushing's syndrome 3
• Itsenko-Cushing syndrome
• Itsenko disease
• pituitary basophilism
• pituitary-dependent hypercorticalism
• suprarenogenic syndrome
• pituitary ACTH hypersecretion
• Cushing disease
• Cushing's disease

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