3A50.4 Hereditary persistence of fetal haemoglobin

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2026-01

Hereditary persistence of fetal haemoglobin (HPFH) associated with beta-thalassaemia is a haemoglobinopathy characterised by high haemoglobin (Hb)F levels and an increased number of fetal-Hb-containing cells. The association of HPFH with beta-thalassaemia mitigates the clinical manifestations which vary from a normal state to beta-thalassaemia intermedia.

synonyms

• Hereditary persistence of fetal haemoglobin
• HPFH - [Hereditary persistence of fetal haemoglobin]
• fetal haemoglobin
• persistence of fetal haemoglobin
• persistent haemoglobin F
• Hereditary persistence of fetal haemoglobin, deletional
• Hereditary persistence of fetal haemoglobin, non-deletional

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