4A85.00 Drug-induced liver hypersensitivity disease

International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2024-01

Drug-induced liver hypersensitivity disease is a relatively rare condition, but can have serious consequences for the individual patient, public health, regulatory agencies and the pharmaceutical industry. It is characterised by elevation in serum alanine-aminotransferase (ALT), conjugated bilirubin, or combined bilirubin, ALT and alkaline phosphatase (AP) levels > 2 times the upper limit of normal (ULN) and the most frequent related drugs are halothane, tienilic acid, dihydralazine, diclofenac, and carbamazepine.

postcoordination

synonyms

• Drug-induced liver hypersensitivity disease
• medicament-induced liver hypersensitivity disease
• Immune-mediated DILI - [drug-induced liver injury]

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