The detection of skin antibodies assists in the diagnosis of chronic vesicular-bullous diseases such as pemphigus and pemphigoid. When patient sera are incubated on monkey or guinea pig esophagus sections, anti-skin antibodies present in the serum will bind with disease-specific patterns by immunofluorescence. For example, the intercellular (IC) antibody pattern diagnoses pemphigus with a 90% sensitivity. Testing with the 2 different species of esophagus sections (monkey and guinea pig) assists in distinguishing different forms of pemphigus. Antibodies following a basement membrane pattern are present in bullous pemphigoid (70%), vesicular pemphigoid (50%) and cicatricial pemphigoid (10%).
status
ACTIVE
Fully-Specified Name
component
Skin Ab.IgG pattern
property
Imp = Impression/interpretation of study
time
Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
system
Ser = Serum
scale
Nom = Nominal: Nominal or categorical responses that do not have a natural ordering. (e.g., names of bacteria, reported as answers, categories of appearance that do not have a natural ordering, such as, yellow, clear, bloody.
method
Monkey esophagus substrate
Additional Names
short name
Immune globulin G; Immunoglobulin G; Impression; Impression/interpretation of study; Impressions; Integument; Interp; Interpretation; Nominal; Point in time; Random; Serology; Serum; SR
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