Carbapenemase [Type] in Isolate by Carba NP 74676-8
LOINC Code
| LOINC code | 74676-8 | ||
|---|---|---|---|
| name | Carbapenemase [Type] in Isolate by Carba NP | ||
| description | The Carba NP (Carbapenemase Nordmann-Poirel) test rapidly (<2 hrs) detects carbapenemase production in isolates of Enterobacteriaceae and Pseudomonas aeruginosa. Carbapenemases are detected and can be differentiated by the CarbaNP test when the test isolate produces the enzyme (in the absence of a chemical inhibitor) that hydrolyzes imipenem (a carbapenem antibiotic) into the carboxylic form of the antibiotic, thereby lowering the pH of the reaction solution which contains phenol red indicator. The acidification changes the red color of the reaction solution to orange-yellow color (positive result) that can be visualized easily with the naked eye. Carba NP testing can detect the following carbapenemase types: Klebsiella pneumoniae carbapenemase (KPC; Ambler class A); Verona integron-encoded metallo-β-lactamase (VIM), imipenemase (IMP), New Delhi metallo-β-lactamase (NDM) (all Ambler class B); and oxacillinase-48 (OXA-48; Ambler class D). For this test, each test isolate is inoculated into 4 reaction wells or tubes: one without any antibiotic or chemical inhibitor against carbapenemases, one containing imipenem without any chemical inhibitor, one containing impenem and tazobactam (which inhibits KPC carbapenemases), one containing imipenem and EDTA (which inhibits VIM, IMP, and NDM carbapenemases). Based on the presence and absence of color change among the 4 reaction wells or tubes, one can differentiate among the 3 classes of carbapenemases. However, differentiation is not possible with this test in isolates that produce more than one class of carbapenemases simultaneously. | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | Carbapenemase | ||
| property | Type = Type: The Property Type is used for assays that identify the specific analyte in cases when the baseline presence of the analyte is known. | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | Isolate | ||
| scale | Nom = Nominal: Nominal or categorical responses that do not have a natural ordering. (e.g., names of bacteria, reported as answers, categories of appearance that do not have a natural ordering, such as, yellow, clear, bloody. | ||
| method | Carbapenemase Nordmann-Poirel | ||
Additional Names | |||
| short name | Carbapenemase Islt | ||
Basic Attributes | |||
| class | MICRO | ||
| type | 1 Laboratory | ||
| order vs. observation | Both | ||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
History/Usage | |||
| test rank | 17381 of 2000 most commonly performed tests by labs in USA | ||
| first released | |||
| last updated | 2.73 | ||
| last change type | MIN - change to field other than name | ||
Related Names | |||
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