Chromosome 17 copy number/nucleus in Tissue by FISH 74861-6
LOINC Code
| LOINC code | 74861-6 | ||||
|---|---|---|---|---|---|
| name | Chromosome 17 copy number/nucleus in Tissue by FISH | ||||
| description | The average number of Chromosome 17 fluorescent signals in nuclei are determined in order to calculate the average ratio of HER2 to Chromosome 17 copy number [LOINC: 49683-6]. This term is based on, but not limited in use to, the PathVysion HER-2 DNA Probe Kit, which detects amplification of the ERBB2 gene (HER2 locus) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded human breast and gastric cancer tissue specimens. The kit contains two probes: one specific to the HER-2/neu gene locus (ERBB2 gene, 17q11.2-q12) and another targeting the alpha satellite DNA sequence at the centromeric region of chromosome 17 (17p11.1-q11.1), called CEP17 (Chromosome Enumeration Probe 17). The average number of HER2 signals [LOINC: 74860-8] along with CEP17 signals are determined by microscopic examination within the same set of nuclei. The specimen is positive for ERBB2 gene applification if the mean ratio of HER2 to CEP17 signals per nucleus is greater than or equal to 2.00. | ||||
| status | ACTIVE | ||||
Fully-Specified Name | |||||
| component | Chromosome 17 copy number/nucleus | ||||
| property | EntNum = Entitic Number | ||||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||||
| system | Tiss = Tissue, unspecified | ||||
| scale | Qn = Quantitative: The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256 | ||||
| method | FISH | ||||
Additional Names | |||||
| short name | Chr 17 copy num/nucleus EntNum Tiss FISH | ||||
Basic Attributes | |||||
| class | MOLPATH | ||||
| type | 1 Laboratory | ||||
| order vs. observation | Observation | ||||
| example UCUM units | {#} The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org) | ||||
| example unit | # | ||||
Associated Observations | |||||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||||
Member of these Panels | |||||
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History/Usage | |||||
| test rank | 11691 of 2000 most commonly performed tests by labs in USA | ||||
| first released | |||||
| last updated | 2.73 | ||||
| last change type | MIN - change to field other than name | ||||
| change reason | Updated Component from "CEP17 signals" to "Chromosome 17 copy number" to align with current nomenclature and similar terms | ||||
Related Names | |||||
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Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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