75694-0

LOINC Code


LOINC code75694-0
name
descriptionDetects E6/E7 viral messenger RNA (mRNA) of human papillomavirus (HPV) types 18 and 45 in cervical specimens from women with positive HPV assay results. E6/E7 oncogenes must be expressed for malignant transformation. For women 21-years and older with atypical squamous cells of undetermined significance (ASC-US) cervical cytology results, and HPV positive assay results, this assay can be used to assess the presence or absence of high-risk HPV genotypes 18, and/or 45. For women 30-years and older, the HPV 18, and/or 45 genotype assay can be used to test samples from women with HPV assay positive results, along with cervical cytology results. This assay has not been evaluated for HPV vaccinated patients or in cases of suspected abuse. It does not differentiate HPV 18 and HPV 45. This term was created for, but not limited in use to, the Aptima HPV 16 18/45 genotype assay which uses target capture, target amplification by transcription-mediated amplification and detection of the amplification products by hybridization protection. To report results for HPV 16 see Human papilloma virus 16 E6+E7 mRNA [Presence] in Cervix by Probe and signal amplification method [LOINC: 82456-5].
statusACTIVE

Fully-Specified Name

componentHuman papilloma virus 18+45 E6+E7 mRNA
propertyPrThr  =  Present or threshold:  The Property PrThr stands for “Presence or Threshold”, meaning either a) the actual presence or absence of an analyte, or b) that the amount of analyte detected is over some predetermined threshold.
timePt  =  Point in time:  To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements.
systemCvx  =  Cervix
scaleOrd  =  Ordinal:  Ordered categorical responses, e.g., 1+, 2+, 3+; positive, negative; reactive, indeterminate, nonreactive.
methodProbe.amp.tar

Additional Names

short name3 Self-Sustaining Sequence Replication; 3SR SR; Amplif; Amplification; Amplified; Cervix; DNA NUCLEIC ACID PROBE; DNA probe; Genital tract; Genital warts; Gyn; Gynecology; HPV; HPV 18; HPV 45; HPV18; HPV18+45 E6+E7 mRNA; Human papilloma virus; Human papil

Basic Attributes

classMICRO
type1  Laboratory
order vs. observationHPV18+45 E6+E7

Member of these Panels

82457-3
90988-7
90988-7

History/Usage

first released
last updated2.73
last change typeMIN  - change to field other than name

Related Names



Copyright © 2026 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2026, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.

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