77353-1
LOINC Code
| LOINC code | 77353-1 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| name | |||||||||
| description | This term was created for, but is not limited in use to, Exact Sciences' Cologuard DNA screening test for colorectal cancer. The Cologuard algorithm includes two laboratory procedures performed on a single stool specimen: 1) detection and quantification of fecal occult blood using ELISA; and 2) detection of multiple genetic biomarkers (NDRG4 and BMP3 methylation targets, seven KRAS point mutations, and beta actin as a proxy for the total amount of human DNA in each sample) using magnetic bead based oligonucleotide hybrid capture to isolate the biomarkers followed by quantitative real-time target and signal amplification. The occult blood and genetic biomarker results are subsequently entered into a logistic regression model, and the results from this model are used to calculate a composite score from which the final binary result (positive, negative) is determined. [PMID: 24645800] | ||||||||
| status | ACTIVE | ||||||||
Fully-Specified Name | |||||||||
| component | Noninvasive colorectal cancer DNA+occult blood screening | ||||||||
| property | Imp = Impression/interpretation of study | ||||||||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||||||||
| system | Stool = Stool = Fecal | ||||||||
| scale | Nar = Narrative: Text narrative, such as the description of a microscopic part of a surgical papule test. | ||||||||
| method | |||||||||
Additional Names | |||||||||
| short name | Asympt; Asymptomatic; Bowel movement; Deoxyribonucleic acid; Faecal; Faeces; Fecal; Feces; Impression; Impression/interpretation of study; Impressions; Interp; Interpretation; Molecular pathology; MOLPATH; Narrative; Noninv colon ca DNA+occ bld screen; Oc | ||||||||
Basic Attributes | |||||||||
| class | MOLPATH | ||||||||
| type | 1 Laboratory | ||||||||
| order vs. observation | Noninv colon ca | ||||||||
Member of these Panels | |||||||||
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History/Usage | |||||||||
| first released | |||||||||
| last updated | 2.73 | ||||||||
| last change type | MIN - change to field other than name | ||||||||
Related Names | |||||||||
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