77354-9
LOINC Code
| LOINC code | 77354-9 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| name | |||||||||
| description | This term was created for, but is not limited in use to, Exact Sciences' Cologuard DNA screening test for colorectal cancer. The Cologuard algorithm includes two laboratory procedures performed on a single stool specimen: 1) detection and quantification of fecal occult blood using ELISA; and 2) detection of multiple genetic biomarkers (NDRG4 and BMP3 methylation targets, seven KRAS point mutations, and beta actin as a proxy for the total amount of human DNA in each sample) using magnetic bead based oligonucleotide hybrid capture to isolate the biomarkers followed by quantitative real-time target and signal amplification. The occult blood and genetic biomarker results are subsequently entered into a logistic regression model, and the results from this model are used to calculate a composite score from which the final binary result (positive, negative) is determined. [PMID: 24645800] | ||||||||
| status | ACTIVE | ||||||||
Fully-Specified Name | |||||||||
| component | Noninvasive colorectal cancer DNA+occult blood screening | ||||||||
| property | PrThr = Present or threshold: The Property PrThr stands for “Presence or Threshold”, meaning either a) the actual presence or absence of an analyte, or b) that the amount of analyte detected is over some predetermined threshold. | ||||||||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||||||||
| system | Stool = Stool = Fecal | ||||||||
| scale | Ord = Ordinal: Ordered categorical responses, e.g., 1+, 2+, 3+; positive, negative; reactive, indeterminate, nonreactive. | ||||||||
| method | |||||||||
Additional Names | |||||||||
| short name | Asympt; Asymptomatic; Bowel movement; Deoxyribonucleic acid; Faecal; Faeces; Fecal; Feces; Molecular pathology; MOLPATH; Noninv colon ca DNA+occ bld screen; Occ; Ordinal; Point in time; PR; QL; Qual; Qualitative; Random; Scn; Screen; Stl; Stool = Fecal | ||||||||
Basic Attributes | |||||||||
| class | MOLPATH | ||||||||
| type | 1 Laboratory | ||||||||
| order vs. observation | Noninv colon ca | ||||||||
Member of these Panels | |||||||||
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History/Usage | |||||||||
| first released | |||||||||
| last updated | 2.73 | ||||||||
| last change type | MIN - change to field other than name | ||||||||
Related Names | |||||||||
Copyright © 2026 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2026, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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