77925-6
LOINC Code
| LOINC code | 77925-6 | ||
|---|---|---|---|
| name | |||
| description | Timed cortisol levels are obtained for adrenocorticotropic hormone challenge tests to assist in diagnosing adrenocortical insufficiency as found in Cushing's syndrome and Addison's disease. There are different types of challenges. ACTH (adrenocorticotropic hormone) stimulation, where cosyntropin (a synthetic form of ACTH) is given, and then blood is sampled for cortisol levels before the bolus, and at specified times after the bolus. The ACTH stimulation directly evaluates adrenal gland function and indirectly evaluates pituitary gland and hypothalamus function. Cortisol levels rise significantly after administration of cosyntropin if the adrenal glands are functioning normally. For the CRH (corticotropin-releasing hormone) stimulation, CRH is given and cortisol and ACTH levels are determined before the injection, at the injection time, and specified times following injection. The CRH stimulation test is used to distinguish Cushings disease from conditions where ACTH is secreted ectopically. For the Dexamethasone suppression (overnight) test (DST), dexamethasone (Decadron) is given and samples for cortisol levels are collected the following morning. The DST differentiates the causes of increased cortisol levels. For the Metyrapone (overnight) stimulation challenge, metyrapone is given with a snack at midnight. Samples for cortisol, 11-deoxycortisol, and ACTH are collected the following morning. The metyrapone stimulation test distinguishes corticotropin-dependent causes (pituitary Cushing's disease and ectopic Cushing's disease) from corticotropin-independent causes (carcinoma of the lung or thyroid) of increased cortisol levels. | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | Cortisol^10M post XXX challenge 10M = 10 minutes post challenge | ||
| property | SCnc = Substance Concentration | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | Ser/Plas Ser = Serum Plas = Plasma | ||
| scale | Qn = Quantitative: The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256 | ||
| method | |||
Additional Names | |||
| short name | 10M p chal; 17-Hydroxycorticosterone; After; CHEMISTRY.CHALLENGE TESTING; Compound F; Coritsol; Cort; F; hydrocortisone; Level; p chal; Pl; Plasma; Plsm; Point in time; PST; QNT; Quan; Quant; Quantitative; Random; SerP; SerPl; SerPlas; Serum; Serum or pla | ||
Basic Attributes | |||
| class | CHAL | ||
| type | 1 Laboratory | ||
| order vs. observation | Cortis 10M p ch | ||
| example UCUM units | nmol/L The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org) | ||
Member of these Groups | |||
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History/Usage | |||
| first released | |||
| last updated | 2.58 | ||
| last change type | MIN - change to field other than name | ||
| change reason | nmol/L | ||
Related Names | |||
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