78993-3
LOINC Code
| LOINC code | 78993-3 | ||||||||||||||||
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| name | |||||||||||||||||
| description | The prolactin isoforms panel includes individual tests for monomeric, dimeric, and macroprolactin, as well as fraction terms for each isomer and an interpretation based on all of the results. Monomeric prolactin is the most common form of circulating prolactin. The dimeric form ("big-prolactin") has a molecular weight of ~50 kD, and polymeric form ("big-big prolactin") has a molecular weight of ~ 150 kD). Big-big prolactin, known as macroprolactin, and big prolactin are formed in the circulation after secretion of prolactin from the pituitary. They have a longer half-life than monomeric prolactin and are not biologically active. However, typical prolactin assays do not differentiate between the different forms of prolactin, and the presence of big and big-big prolactin can lead to a false diagnosis of hyperprolactinemia. Methods such as PEG precipitation can separate macroprolactin and big prolactin from monomeric prolactin in order to obtain a more accurate measurement of biologically active prolactin, and chromatography can be used to further characterize the isoforms if necessary. [PMCID: PMC3719302] | ||||||||||||||||
| status | ACTIVE | ||||||||||||||||
Fully-Specified Name | |||||||||||||||||
| component | Prolactin isoforms panel | ||||||||||||||||
| property | - | ||||||||||||||||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||||||||||||||||
| system | Ser/Plas Ser = Serum Plas = Plasma | ||||||||||||||||
| scale | - | ||||||||||||||||
| method | |||||||||||||||||
Additional Names | |||||||||||||||||
| short name | Chemistry; Lactotropic hormone; Lactotropin; Mammatropic hormone; Mammotropin; Pan; PANEL.CHEMISTRY; Panl; Pl; Plasma; Plsm; Pnl; Point in time; PRL; Prol; Prolactin isoforms Pnl; Random; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR | ||||||||||||||||
Basic Attributes | |||||||||||||||||
| class | PANEL.CHEM | ||||||||||||||||
| type | 1 Laboratory | ||||||||||||||||
| order vs. observation | Prolactin isofo | ||||||||||||||||
Panel Components | |||||||||||||||||
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History/Usage | |||||||||||||||||
| first released | |||||||||||||||||
| last updated | 2.54 | ||||||||||||||||
| last change type | MIN - change to field other than name | ||||||||||||||||
Related Names | |||||||||||||||||
Copyright © 2026 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2026, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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