IgM clearance/Albumin clearance [Ratio] in Serum and CSF 79406-5
LOINC Code
| LOINC code | 79406-5 | ||
|---|---|---|---|
| name | IgM clearance/Albumin clearance [Ratio] in Serum and CSF | ||
| description | CSF IgM, IgA, and IgG indexes are indicators of intrathecal immunoglobulin synthesis. The calculations incorporate the CSF-serum albumin quotient, an indicator of blood-brain-barrier (BBB) function, in order to differentiate whether the immunoglobulins found in the CSF were produced intrathecally or leaked across the BBB. These immunoglobulin indexes can be useful in the diagnosis of central nervous system infections, neoplasms and primary neurologic diseases such as multiple sclerosis. They also have the potential to monitor treatment efficacy in conditions such as systemic lupus erythematosus with CNS involvement, in which one study found that all three indexes decreased significantly along with CNS symptoms during successful treatment. The CSF IgM index is calculated as (CSF IgM/serum IgM)/(CSF albumin/serum albumin), which can also be represented as (CSF IgM x serum albumin)/(serum IgM x CSF albumin). [PMID: 3899036] | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | IgM clearance/Albumin clearance | ||
| property | Ratio | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | Ser+CSF Ser = Serum CSF = Cerebral spinal fluid | ||
| scale | Qn = Quantitative: The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256 | ||
| method | |||
Additional Names | |||
| short name | IgM/Alb clear Ser+CSF-Rto | ||
Basic Attributes | |||
| class | CHEM | ||
| type | 1 Laboratory | ||
| order vs. observation | Observation | ||
| formula (readable) | IgM index = (CSF IgM/serum IgM)/(CSF albumin/serum albumin) | ||
| example UCUM units | {ratio} The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org) | ||
| example unit | ratio | ||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
History/Usage | |||
| first released | |||
| last updated | 2.54 | ||
| last change type | MIN - change to field other than name | ||
Related Names | |||
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Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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