79574-0
LOINC Code
| LOINC code | 79574-0 | ||
|---|---|---|---|
| name | |||
| description | Testing for folate and its metabolites as well as tryptophan and its metabolites in CSF can be useful in distinguishing among various central nervous system disorders associated with folate deficiency. Low folate levels are associated with inborn errors of metabolism, including cerebral folate deficiency (CFD), a neurological syndrome that occurs around 2-4 months of age and is primarily associated with associated with low levels of 5-methyltetrahydrofolate (5-MTHF) in the CSF with normal folate levels in the plasma and red blood cells.[PMID: 19260931] Low folate levels are also associated with depression and dementia in elderly patients.[PMID: 11183038] Serotonin, which is formed from tryptophan, may be the link between folate and depression or dementia. Many patients with neuropsychiatric disorders and folate deficiency have also been found to have low levels of 5-hydroxyindoleacetic acid (5-HIAA, a serotonin metabolite), and patients with 5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency also have decreased serotonin synthesis. [PMCID: 1810582] | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | Folate & tryptophan & metabolites pattern | ||
| property | Imp = Impression/interpretation of study | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | CSF = Cerebral spinal fluid | ||
| scale | Nar = Narrative: Text narrative, such as the description of a microscopic part of a surgical papule test. | ||
| method | |||
Additional Names | |||
| short name | c244; Cerebral spinal fluid; Cerebrospinal Fl; Chemistry; Folat; Folate + Tryp + Metabs Pattern; Folic acid; Impression; Impression/interpretation of study; Impressions; Interp; Interpretation; L-tryptophan; Metabolite; Metb; Narrative; Point in time; Pte | ||
Basic Attributes | |||
| class | CHEM | ||
| type | 1 Laboratory | ||
| order vs. observation | Folate + Tryp + | ||
Member of these Panels | |||
| |||
History/Usage | |||
| first released | |||
| last updated | 2.83 | ||
| last change type | MIN - change to field other than name | ||
Related Names | |||
| hierarchy paths | LOINC Home {component} LP432695-7 Laboratory LP29693-6 Chemistry and Chemistry - challenge LP343631-0 Chemistry - non-challenge LP7786-9 Amino acids LP18033-8 Tryptophan LP15931-6 Folate and tryptophan and metabolites pattern LP201743-4 Folate and tryptophan and metabolites pattern | Cerebrospinal Fluid | Chemistry - non-challenge LP384409-1 LOINC Home {component} LP432695-7 Laboratory LP29693-6 Chemistry and Chemistry - challenge LP343631-0 Chemistry - non-challenge LP7786-9 Vitamins LP31395-4 Vitamin M LP31701-3 Folate LP15575-1 Folate and tryptophan and metabolites pattern LP201743-4 Folate and tryptophan and metabolites pattern | Cerebrospinal Fluid | Chemistry - non-challenge LP384409-1 | ||
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