Peripheral deiodinase activity [Moles/time] in Serum or Plasma by Calculated.SPINA 82367-4
LOINC Code
| LOINC code | 82367-4 | ||
|---|---|---|---|
| name | Peripheral deiodinase activity [Moles/time] in Serum or Plasma by Calculated.SPINA | ||
| description | The sum activity of peripheral deiodinases (GD, also referred to as deiodination capacity or total deiodinase activity) is the maximum amount of triiodothyronine (T3) produced per time-unit by deiodinases outside the central nervous system. The structure parameter inference approach (SPINA) uses Michaelis-Menten functions and pharmakokinetic data to estimate GD under conditions of substrate saturation. One calculation is based on peripheral free T3 and free T4 values, and an alternate calculation uses peripheral total T3 and free T4. GD calculated using the SPINA approach is also known as SPINA-GD. SPINA-GD may be useful in diagnosing thyroid conditions that are difficult to diagnose based on traditional thyroid function studies, such as subclinical forms of thyroid failure, hypothalamic or pituitary dysfunction, and non-thyroidal illness syndrome. [PMID: 27375554] Thyroid secretory function by SPINA, called SPINA-GT, is a related result [LOINC: 82368-2]. | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | Peripheral deiodinase activity | ||
| property | SRat = Substance Rate | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | Ser/Plas Ser = Serum Plas = Plasma | ||
| scale | Qn = Quantitative: The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256 | ||
| method | Calculated.SPINA | ||
Additional Names | |||
| short name | Per deiod act SerPl Calc SPINA-sRate | ||
Basic Attributes | |||
| class | CHEM | ||
| type | 1 Laboratory | ||
| order vs. observation | Both | ||
| formula (readable) | GD = beta31 * (KM1 + [FT4]) * (1 + K30 * [TBG]) * [FT3] / (alpha31 * [FT4]) or GD = beta31 * (KM1 + [FT4]) * [TT3] / (alpha31 * [FT4]) Please see [PMID: 27375554] for more information for the formula constants, alpha31, beta31, KM1, and K30. | ||
| example UCUM units | nmol/s The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org) | ||
| example unit | nmol/s | ||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
History/Usage | |||
| first released | |||
| last updated | 2.58 | ||
| last change type | ADD - added | ||
Related Names | |||
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Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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