Thyroid secretory capacity [Moles/time] in Serum or Plasma by Calculated.SPINA 82368-2
LOINC Code
| LOINC code | 82368-2 | ||
|---|---|---|---|
| name | Thyroid secretory capacity [Moles/time] in Serum or Plasma by Calculated.SPINA | ||
| description | Thyroid secretory capacity (also called thyroid output or GT) is the maximum secretion rate of the thyroid gland under stimulated conditions. The structure parameter inference approach (SPINA) uses Michaelis-Menten functions and pharmakokinetic data to estimate GT under conditions of substrate saturation. One calculation is based on peripheral TSH, free T4, thyroid binding globulin and thyroid binding prealbumin values, and an alternate calculation uses peripheral TSH and total T4. GT calculated using the SPINA approach is also known as SPINA-GT. SPINA-GT may be useful in diagnosing secondary or tertiary thyroid conditions and has also been shown to be able to clearly differentiate between euthyroidism and functional thyroid disorders of primary origin. [PMID: 27375554] Peripheral deiodinase activity by SPINA, called SPINA-GD, is a related result [LOINC: 82367-4]. | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | Thyroid secretory capacity | ||
| property | SRat = Substance Rate | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | Ser/Plas Ser = Serum Plas = Plasma | ||
| scale | Qn = Quantitative: The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256 | ||
| method | Calculated.SPINA | ||
Additional Names | |||
| short name | Thyr secr cap SerPl Calc SPINA-sRate | ||
Basic Attributes | |||
| class | CHEM | ||
| type | 1 Laboratory | ||
| order vs. observation | Both | ||
| formula (readable) | GT = BetaT * (DT + [TSH]) * (1 + K41 [TBG] + K42 [TBPA]) * [FT4] / (AlphaT * [TSH]) or GT = BetaT * (DT + [TSH]) * [TT4] / (AlphaT * [TSH]) Please see [PMID: 27375554] for more information about the constants, AlphaT, BetaT, K41, K42, TBPA, and DT. | ||
| example UCUM units | pmol/s The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org) | ||
| example unit | pmol/s | ||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
History/Usage | |||
| first released | |||
| last updated | 2.58 | ||
| last change type | ADD - added | ||
Related Names | |||
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Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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