83052-1
LOINC Code
| LOINC code | 83052-1 | |
|---|---|---|
| name | ||
| description | This term should be used to report the presence of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone 22C3. Patients with certain cancers, such as non-small cell lung cancer (NSCLC), whose tumors are positive for PD-L1 by 22C3 are eligible for anti-programmed death 1 (PD-1) receptor antibody therapy with pembrolizumab, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using [LOINC: 83053-9]. A tumor with <50% staining by 22C3 is considered PD-L1 negative, and >= 50% is considered PD-L1 positive. This term was created for, but is not limited in use to, the Dako PD-L1 22C3 pharmDx test kit, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with specific cancers are eligible for pembrolizumab therapy. | |
| status | ACTIVE | |
Fully-Specified Name | ||
| component | Programmed cell death ligand 1 by clone 22C3 | |
| property | PrThr = Present or threshold: The Property PrThr stands for “Presence or Threshold”, meaning either a) the actual presence or absence of an analyte, or b) that the amount of analyte detected is over some predetermined threshold. | |
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | |
| system | Tiss = Tissue, unspecified | |
| scale | Ord = Ordinal: Ordered categorical responses, e.g., 1+, 2+, 3+; positive, negative; reactive, indeterminate, nonreactive. | |
| method | Immune stain | |
Additional Names | ||
| short name | B7 homolog 1; B7-H1; CD274; Cluster of differentiation 274; i; IHC; Imm; Immunohistochemical stain; Immunostain; ImStn; Imun; Imune; Ordinal; PATHOLOGY; PDL1; PD-L1; PD-L1 by 22C3; Point in time; PR; QL; Qual; Qualitative; Random; Screen; St; Stains; Stn; | |
Basic Attributes | ||
| class | PATH | |
| type | 1 Laboratory | |
| order vs. observation | PD-L1 by 22C3 T | |
History/Usage | ||
| first released | ||
| last updated | 2.73 | |
| last change type | MIN - change to field other than name | |
Related Names | ||
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