Tumor mutation burden [Interpretation] 94077-5
LOINC Code
| LOINC code | 94077-5 | ||
|---|---|---|---|
| name | Tumor mutation burden [Interpretation] | ||
| description | Tumor mutational burden (TMB), also known as mutation load, is a biomarker for various cancer types to identify patients who will benefit from immunotherapy, such as immune checkpoint blockade (ICB) therapy. Testing can be performed by whole exome sequencing (WES) or next-generation sequencing (NGS). Various quantitative and ordinal results may be reported, so it is important to distinguish the type of results when mapping to LOINC. Quantitative results typically include the number of mutations detected per megabase (mut/Mb), often by NGS, in a tumor specimen [LOINC: 94076-7]. The mutations targeted may include non-synonymous or both synonymous and non-synonymous mutations. Quantitative TMB results have also been reported as the total number of mutations detected by whole exome sequencing (WES). We encourage labs to report how results are determined or calculated in either the structured message format or using another LOINC. An ordinal TMB result (this term) of high, low, etc., may also be reported to provide an overall interpretation for the quantitative value (muts/Mb). Cut-offs vary across assays and for each tumor type, so it is important to know which assay was used to determine the overall ordinal TMB result. | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | Tumor mutation burden | ||
| property | Imp = Impression/interpretation of study | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | Tumor | ||
| scale | Ord = Ordinal: Ordered categorical responses, e.g., 1+, 2+, 3+; positive, negative; reactive, indeterminate, nonreactive. | ||
| method | |||
Additional Names | |||
| short name | TMB Tumor-Imp | ||
Basic Attributes | |||
| class | MOLPATH.MUT | ||
| type | 1 Laboratory | ||
| order vs. observation | Both | ||
Associated Observations | |||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||
History/Usage | |||
| first released | |||
| last updated | 2.67 | ||
| last change type | ADD - added | ||
Related Names | |||
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Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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