by Janine Mothershed
Jun 9th, 2025
Here's a clear and thorough guide for medical coding and billing for Haemophilus influenzae (H. influenzae) — not to be confused with the flu (influenza virus). This bacterium can cause serious invasive diseases like meningitis, epiglottitis, pneumonia, and sepsis.
Common ICD-10 Diagnosis Codes:
A41.3 | Sepsis due to Haemophilus influenzae |
G00.0 | Haemophilus influenzae meningitis |
J14 | Pneumonia due to Haemophilus influenzae |
J05.1 | Acute epiglottitis |
J20.3 | Acute bronchitis due to H. influenzae |
H66.3 | Otitis media due to H. influenzae |
A49.2 | H. influenzae infection, unspecified site |
Tip: Always choose a specific site code (like J14 or G00.0) when available instead of A49.2 (nonspecific site).
Vaccination Coding for Hib (Haemophilus influenzae type b)
Vaccination is specifically for Hib, primarily in pediatric populations.
CPT Codes – Hib Vaccine:
90644 | Hib-Hep B vaccine (combined) |
90645 | Hib vaccine, PRP-D conjugate |
90646 | Hib vaccine, PRP-OMP conjugate |
90647 | Hib vaccine, PRP-T conjugate |
90648 | Hib vaccine, PRP-T conjugate (different brand) |
Vaccine Administration Codes:
90460 | Vaccine admin with counseling (0–18 years, first vaccine) |
90461 | Admin for each additional component |
90471/90472 | Admin codes without counseling (used in adults or no counseling) |
For information on medical coding flu vaccines, visit: https://codingclarified.com/medical-coding-of-flu-vaccines/
The diagnosis code for immunization is Z23 – Encounter for immunization.
Billing Tips
When treating H. influenzae infection:
- Use the most specific ICD-10 code (e.g., J14 for pneumonia).
- Document organism identification (via culture or PCR).
- If multiple complications are present, code each condition (e.g., meningitis and sepsis).
When billing for Hib vaccine:
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Use Z23 as the primary diagnosis.
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Ensure proper documentation of:
Clinical and Coding Scenarios
Example 1: Hib Meningitis
Example 2: Hib Pneumonia
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ICD-10: J14
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Avoid generic pneumonia codes unless cause is unknown
Example 3: Well-child visit with Hib vaccine
Compliance and Documentation Tips
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Use lab confirmation if billing for a specific organism (especially G00.0 or A41.3).
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Avoid generic infection codes when a specific bacterial etiology is documented.
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When giving the Hib vaccine:
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Check payor-specific policies: Some Medicaid/CHIP plans have unique guidelines for vaccine billing.
Summary Coding Table
Condition - ICD-10 Code - CPT Code (if vaccinated)
Hib Meningitis | G00.0 | — |
Hib Pneumonia | J14 | — |
Hib Sepsis | A41.3 | — |
Hib Otitis Media | H66.3 | — |
Hib Vaccine | Z23 | 90645–90648 + admin |
Janine Mothershed is the founder and CEO of Coding Clarified, an innovative online medical coding school committed to transforming lives through flexible, high-quality career training. A Certified Professional Coder (CPC) and licensed AAPC instructor, Janine brings over a decade of experience in healthcare administration, medical coding, and workforce development.
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