6C43.2 Opioid dependence International Classification of Diseases for Mortality and Morbidity Statistics, 11th Revision, v2025-01 Opioid dependence is a disorder of regulation of opioid use arising from repeated or continuous use of opioids. The characteristic feature is a strong internal drive to use opioids, which is manifested by impaired ability to control use, increasing priority given to use over other activities and persistence of use despite harm or negative consequences. These experiences are often accompanied by a subjective sensation of urge or craving to use opioids. Physiological features of dependence may also be present, including tolerance to the effects of opioids, withdrawal symptoms following cessation or reduction in use of opioids, or repeated use of opioids or pharmacologically similar substances to prevent or alleviate withdrawal symptoms. The features of dependence are usually evident over a period of at least 12 months but the diagnosis may be made if opioid use is continuous (daily or almost daily) for at least 3 months.
exclusions sections/codes in this section (6C43.2-6C43.2) postcoordination Add Stem and/or Extension codes to form a cluster code which adds detail to the condition.
Has manifestation - multiple selections are allowed [select] 6C43.5 Opioid-induced delirium 6C43.6 Opioid-induced psychotic disorder 6C43.7 Certain specified opioid-induced mental or behavioural disorders – 6C43.70 Opioid-induced mood disorder – 6C43.71 Opioid-induced anxiety disorder Associated with - multiple selections are allowed [select] 6C43.3 Opioid intoxication 6C43.4 Opioid withdrawal PB20 Unintentional exposure to or harmful effects of opioids or related analgesics PB21 Unintentional exposure to or harmful effects of sedative hypnotic drugs or other CNS depressants PB22 Unintentional exposure to or harmful effects of psychostimulants PB23 Unintentional exposure to or harmful effects of cannabinoids or hallucinogens PB24 Unintentional exposure to or harmful effects of analgesics, antipyretics or nonsteroidal anti-inflammatory drugs PB25 Unintentional exposure to or harmful effects of antidepressants PB26 Unintentional exposure to or harmful effects of antipsychotics PB27 Unintentional exposure to or harmful effects of antiepileptics or antiparkinsonism drugs PB28 Unintentional exposure to or harmful effects of other or unspecified drug, medicament or biological substance PB29 Unintentional exposure to or harmful effects of multiple drugs, medicaments or biological substances PB30 Unintentional exposure to or harmful effects of alcohols PB31 Unintentional exposure to or harmful effects of organic solvents PB32 Unintentional exposure to or harmful effects of carbon monoxide PB33 Unintentional exposure to or harmful effects of pesticides PB34 Unintentional exposure to or harmful effects of corrosive substances PB35 Unintentional exposure to or harmful effects of halogen derivatives of aliphatic or aromatic hydrocarbons PB36 Unintentional exposure to or harmful effects of other or unspecified substances chiefly nonmedicinal as to source PC90 Intentional self-harm by exposure to or harmful effects of opioids or related analgesics PC91 Intentional self-harm by exposure to or harmful effects of sedative hypnotic drugs or other CNS depressants PC92 Intentional self-harm by exposure to or harmful effects of psychostimulants PC93 Intentional self-harm by exposure to or harmful effects of cannabinoids or hallucinogens PC94 Intentional self-harm by exposure to or harmful effects of analgesics, antipyretics or nonsteroidal anti-inflammatory drugs PC95 Intentional self-harm by exposure to or harmful effects of antidepressants PC96 Intentional self-harm by exposure to or harmful effects of antipsychotics PC97 Intentional self-harm by exposure to or harmful effects of antiepileptics or antiparkinsonism drugs PC98 Intentional self-harm by exposure to other or unspecified drug, medicament or biological substance PC99 Intentional self-harm by exposure to or harmful effects of multiple drugs, medicaments or biological substances PD00 Intentional self-harm by exposure to or harmful effects of alcohols PD01 Intentional self-harm by exposure to or harmful effects of organic solvents PD02 Intentional self-harm by exposure to or harmful effects of carbon monoxide PD03 Intentional self-harm by exposure to or harmful effects of pesticides PD04 Intentional self-harm by exposure to or harmful effects of corrosive substances PD05 Intentional self-harm by exposure to or harmful effects of other or unspecified substances chiefly nonmedicinal as to source PH40 Exposure to or harmful effects of undetermined intent of opioids or related analgesics PH41 Exposure to or harmful effects of undetermined intent of sedative hypnotic drugs or other CNS depressants PH42 Exposure to or harmful effects of undetermined intent of psychostimulants PH43 Exposure to or harmful effects of undetermined intent of cannabinoids or hallucinogens PH44 Exposure to or harmful effects of undetermined intent of analgesics, antipyretics or nonsteroidal anti-inflammatory drugs PH45 Exposure to or harmful effects of undetermined intent of antidepressants PH46 Exposure to or harmful effects of undetermined intent of antipsychotics PH47 Exposure to or harmful effects of undetermined intent of antiepileptics or antiparkinsonism drugs – PH47.0 Harmful effects of or exposure to mixed antiepileptics, not elsewhere classified, undetermined intent – PH47.Z Undetermined intent: Harmful effects of and exposure to noxious substances: Drugs, medicaments or biological substances: Unspecified antiepileptics or antiparkinsonism drugs PH48 Exposure to or harmful effects of undetermined intent of other or unspecified drugs, medicaments or biological substances PH49 Exposure to or harmful effects of undetermined intent of multiple drugs, medicaments or biological substances PH50 Exposure to or harmful effects of undetermined intent of alcohols PH51 Exposure to or harmful effects of undetermined intent of organic solvents PH52 Exposure to or harmful effects of undetermined intent of carbon monoxide PH53 Exposure to or harmful effects of undetermined intent of pesticides PH54 Exposure to or harmful effects of undetermined intent of corrosive substances PH55 Exposure to or harmful effects of undetermined intent of halogen derivatives of aliphatic or aromatic hydrocarbons PH56 Exposure to or harmful effects of undetermined intent of other or unspecified substances chiefly nonmedicinal as to source PL00 Drugs, medicaments or biological substances associated with injury or harm in therapeutic use PL01 Complementary or traditional medicines associated with injury or harm in therapeutic use PL01.0 Complementary or traditional medicines associated with injury or harm in therapeutic use, Herbal Preparations or Formulas PL01.1 Complementary or traditional medicines associated with injury or harm in therapeutic use, Dietary Supplements, Vitamins or Minerals PL01.2 Complementary or traditional medicines associated with injury or harm in therapeutic use, Complementary or Traditional Medicines, not elsewhere classified PL01.Y Other specified complementary or traditional medicines associated with injury or harm in therapeutic use PL01.Z Complementary or traditional medicines associated with injury or harm in therapeutic use, unspecified PL0Z Substances associated with injury or harm in therapeutic use, unspecified
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