ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH 49683-6
LOINC Code
| LOINC code | 49683-6 | ||||
|---|---|---|---|---|---|
| name | ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH | ||||
| description | The ratio of HER-2/neu (ERBB2 gene) to CEP17 probes by in situ hybridization assays (e.g. FISH) to determine overexpression of HER-2/neu protein in breast cancer. CEP17 is used as an internal control and to account for aneusomy (varying number) of chromosome 17. A ratio of >2.0 indicates gene amplification and overexpression of HER-2/neu according to the 2013 ASCO-CAP HER2 test guideline recommendations. Results are used to assist in dose selection for certain drugs, assess eligibility for trastuzumab (Herceptin®) treatment, predict response to drug therapies and overall survival in patients with breast cancer. For testing without an internal control probe, see LOINCs 31150-6 and 48675-3. For determining HER-2 status by Immunohistochemistry (IHC), see LOINC 18474-7. | ||||
| status | ACTIVE | ||||
Fully-Specified Name | |||||
| component | ERBB2 gene copy number/Chromosome 17 copy number | ||||
| property | NRto = Number Ratio | ||||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||||
| system | Tiss = Tissue, unspecified | ||||
| scale | Qn = Quantitative: The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256 | ||||
| method | FISH | ||||
Additional Names | |||||
| short name | ERBB2 copy num/Chr 17 copy num Tiss FISH | ||||
Basic Attributes | |||||
| class | MOLPATH | ||||
| type | 1 Laboratory | ||||
| order vs. observation | Both | ||||
Associated Observations | |||||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||||
Member of these Panels | |||||
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History/Usage | |||||
| test rank | 7211 of 2000 most commonly performed tests by labs in USA | ||||
| first released | |||||
| last updated | 2.73 | ||||
| last change type | MIN - change to field other than name | ||||
| change reason | Release 2.70: COMPONENT: Corrected the gene name based on the LOINC model to use the approved HGNC name for the gene that encodes the HER2 receptor.; Previous Releases: Updated Component from "HER2/CEP17" and Property from "Ratio" to align with current nomenclature and similar terms | ||||
Related Names | |||||
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Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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