72312-2
LOINC Code
| LOINC code | 72312-2 | ||
|---|---|---|---|
| name | |||
| description | A translocation involving chromosomes 1 and 19, t(1;19)(q23;p13), results in a fused transcript between TCF3 (formerly E2A) and PBX1 (formerly prl) genes. The TCF3-PBX1 fusion gene is found in approximately 3% of childhood and adult precursor-B acute lymphoblastic leukemia (ALL). This code is based on, but not limited to, Ispogen's E2A-PBX1 FusionQuant® kit, which uses real-time Quantitative RQ-PCR to quantify the expression level of specific TCF3(E2A)-PBX1 fusion gene transcripts relative to a control gene transcript (e.g. ABL1). From the manufacturer's website (2012), "Quantification of E2A-PBX1 fusion gene transcripts has been standardized in the EAC (Europe Against Cancer) program [Gabert J et al. Leukemia. 2003, Beillard E et al. Leukemia. 2003], and IPSOGEN FusionQuant® kits use this validated technology to calibrate and normalize RQ-PCR results." | ||
| status | ACTIVE | ||
Fully-Specified Name | |||
| component | t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript | ||
| property | NRto = Number Ratio | ||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||
| system | Bld/Tiss Bld = Whole blood Tiss = Tissue, unspecified | ||
| scale | Qn = Quantitative: The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256 | ||
| method | Molgen = Molecular Genetics: General class of methods used to detect genetic attributes on a molecular basis including RFL, PCR and other methods. | ||
Additional Names | |||
| short name | ABL; ABL1; ABL1 transcript; Acute lymphoblastic leukaemia; Acute lymphoblastic leukemia; Acute myeloid leukemia; ALL; AML; Blood; control gene; DNA; E2A Immunoglobulin enhancer binding factors E12/E47; gene fusion; gene translocation; Genetics; Heredity; | ||
Basic Attributes | |||
| class | MOLPATH.TRNLOC | ||
| type | 1 Laboratory | ||
| order vs. observation | t(1;19)(PBX1,TC | ||
| example UCUM units | % The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org) | ||
Member of these Panels | |||
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History/Usage | |||
| first released | |||
| last updated | 2.42 | ||
| last change type | MIN - change to field other than name | ||
| change reason | % | ||
Related Names | |||
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