74860-8
LOINC Code
| LOINC code | 74860-8 | ||||
|---|---|---|---|---|---|
| name | |||||
| description | The average number of fluorescent signals targeting the ERBB2 gene (HER2 locus) in nuclei are determined in order to calculate the average ratio of ERBB2 gene to Chromosome 17 copy number [LOINC: 49683-6]. This term is based on, but not limited in use to, the PathVysion HER-2 DNA Probe Kit, which detects amplification of the ERBB2 gene via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded human breast and gastric cancer tissue specimens. The kit contains two probes: one specific to the HER-2/neu gene locus (ERBB2 gene, 17q11.2-q12) and another targeting the alpha satellite DNA sequence at the centromeric region of chromosome 17 (17p11.1-q11.1), called CEP17 (Chromosome Enumeration Probe 17). The average number of HER2 signals along with CEP17 signals [LOINC: 74861-6] are determined by microscopic examination within the same set of nuclei. The specimen is positive for ERBB2 gene amplification if the mean ratio of HER2 to CEP17 signals per nucleus is greater than or equal to 2.00. | ||||
| status | ACTIVE | ||||
Fully-Specified Name | |||||
| component | ERBB2 gene copy number/nucleus | ||||
| property | EntNum = Entitic Number | ||||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||||
| system | Tiss = Tissue, unspecified | ||||
| scale | Qn = Quantitative: The result of the test is a numeric value that relates to a continuous numeric scale. Reported either as an integer, a ratio, a real number, or a range. The test result value may optionally contain a relational operator from the set {<=, <, >, >=}. Valid values for a quantitative test are of the form "7", "-7", "7.4", "-7.4", "7.8912", "0.125", "<10", "<10.15", ">12000", 1-10, 1:256 | ||||
| method | FISH | ||||
Additional Names | |||||
| short name | breast cancer; CD340; c-erb B2; Entitic; Entitic number; ErbB-2; ERBB2 copy num; erb-b2 receptor tyrosine kinase 2; Fluorescent in situ hybridization; Genetics; HER2; HER-2; HER2/neu; HER-2/neu; Heredity; Heritable; Inherited; MLN 19; Molecular pathology; | ||||
Basic Attributes | |||||
| class | MOLPATH | ||||
| type | 1 Laboratory | ||||
| order vs. observation | ERBB2 copy num/ | ||||
| example UCUM units | # The Unified Code for Units of Measure (UCUM) is a code system intended to include all units of measures being contemporarily used in international science, engineering, and business (www.unitsofmeasure.org) | ||||
Member of these Panels | |||||
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History/Usage | |||||
| first released | |||||
| last updated | 2.73 | ||||
| last change type | MIN - change to field other than name | ||||
| change reason | {#} | ||||
Related Names | |||||
Copyright © 2026 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2026, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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