75515-7
LOINC Code
| LOINC code | 75515-7 | ||||||||||||||||||||||||||||||||||||||||||||||||
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| name | |||||||||||||||||||||||||||||||||||||||||||||||||
| description | The development of this panel for detecting Lupus Anticoagulant (LA) was shaped by the 2009 International Society of Thrombosis and Haemostasis (ISTH) and 2014 Clinical and Laboratory Standards Institute (CLSI) guidelines for lupus anticoagulant testing. They both recommend using two separate coagulation tests and identify dRVVT and aPPT as the two best choices. This aPPT & dRVVT panel is most closely aligned with the ISTH guidelines. The testing cascade starts with the use of the two above-named tests to screen for or verify a clotting abnormality, and if either is abnormal, reflexing to the same test with 1:1 pooled plasma (to exclude clotting factor deficiencies) and again with excess phospholipid (PL). Correction of the coagulopathy with excess phospholipid confirms the likelihood of LA. Neither published guidance nor laboratories agree on the order in which the two kinds of reflex tests should be done, and this panel does not take a position on that subject. Some laboratories report the absolute values of the test and some the normalized ratios. So LOINC includes both as alternatives. Only one or the other of the alternatives must be included in the panel report. A summary interpretation is required by both guidelines. | ||||||||||||||||||||||||||||||||||||||||||||||||
| status | ACTIVE | ||||||||||||||||||||||||||||||||||||||||||||||||
Fully-Specified Name | |||||||||||||||||||||||||||||||||||||||||||||||||
| component | Lupus anticoagulant two screening tests W Reflex panel | ||||||||||||||||||||||||||||||||||||||||||||||||
| property | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||||||||||||||||||||||||||||||||||||||||||||||||
| system | PPP = Platelet poor plasma | ||||||||||||||||||||||||||||||||||||||||||||||||
| scale | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| method | Coag = Coagulation Assay: To distinguish coagulation assays based on clotting methods that test function/activity from Immune methods that detect the presence of clotting factors and may or may not be functional assays. | ||||||||||||||||||||||||||||||||||||||||||||||||
Additional Names | |||||||||||||||||||||||||||||||||||||||||||||||||
| short name | 2; Anticoag; Anti-phospholipid antibody; aPTT-LA; Asympt; Asymptomatic; Clot; Clottable; COAGULATION; Coagulation assay; Coagulation inhibiting antibody; Dil Russell Vip Ven; dRVVT; LA; LA 2 screen W Reflex; LA 2 screen W Reflex pnl; LAC; Lupus inhibitor; | ||||||||||||||||||||||||||||||||||||||||||||||||
Basic Attributes | |||||||||||||||||||||||||||||||||||||||||||||||||
| class | PANEL.COAG | ||||||||||||||||||||||||||||||||||||||||||||||||
| type | 1 Laboratory | ||||||||||||||||||||||||||||||||||||||||||||||||
| order vs. observation | LA aPTT+dRVVT s | ||||||||||||||||||||||||||||||||||||||||||||||||
Panel Components | |||||||||||||||||||||||||||||||||||||||||||||||||
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History/Usage | |||||||||||||||||||||||||||||||||||||||||||||||||
| first released | |||||||||||||||||||||||||||||||||||||||||||||||||
| last updated | 2.67 | ||||||||||||||||||||||||||||||||||||||||||||||||
| last change type | PANEL - addition or removal of child elements or change in the conditionality of child elements in the panel or in sub-panels contained by the panel. | ||||||||||||||||||||||||||||||||||||||||||||||||
Related Names | |||||||||||||||||||||||||||||||||||||||||||||||||
Copyright © 2026 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2026, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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