Noninvasive colorectal cancer DNA and occult blood screening [Interpretation] in Stool Narrative 77353-1
LOINC Code
| LOINC code | 77353-1 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| name | Noninvasive colorectal cancer DNA and occult blood screening [Interpretation] in Stool Narrative | ||||||||
| description | This term was created for, but is not limited in use to, Exact Sciences' Cologuard DNA screening test for colorectal cancer. The Cologuard algorithm includes two laboratory procedures performed on a single stool specimen: 1) detection and quantification of fecal occult blood using ELISA; and 2) detection of multiple genetic biomarkers (NDRG4 and BMP3 methylation targets, seven KRAS point mutations, and beta actin as a proxy for the total amount of human DNA in each sample) using magnetic bead based oligonucleotide hybrid capture to isolate the biomarkers followed by quantitative real-time target and signal amplification. The occult blood and genetic biomarker results are subsequently entered into a logistic regression model, and the results from this model are used to calculate a composite score from which the final binary result (positive, negative) is determined. [PMID: 24645800] | ||||||||
| status | ACTIVE | ||||||||
Fully-Specified Name | |||||||||
| component | Noninvasive colorectal cancer DNA+occult blood screening | ||||||||
| property | Imp = Impression/interpretation of study | ||||||||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||||||||
| system | Stool = Stool = Fecal | ||||||||
| scale | Nar = Narrative: Text narrative, such as the description of a microscopic part of a surgical papule test. | ||||||||
| method | |||||||||
Additional Names | |||||||||
| short name | Noninv colon ca DNA+occ bld scrn Stl-Imp | ||||||||
Basic Attributes | |||||||||
| class | MOLPATH | ||||||||
| type | 1 Laboratory | ||||||||
| order vs. observation | Observation | ||||||||
Associated Observations | |||||||||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||||||||
Member of these Panels | |||||||||
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History/Usage | |||||||||
| test rank | 4228 of 2000 most commonly performed tests by labs in USA | ||||||||
| first released | |||||||||
| last updated | 2.73 | ||||||||
| last change type | MIN - change to field other than name | ||||||||
Related Names | |||||||||
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Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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