Noninvasive colorectal cancer DNA and occult blood screening [Presence] in Stool 77354-9
LOINC Code
| LOINC code | 77354-9 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| name | Noninvasive colorectal cancer DNA and occult blood screening [Presence] in Stool | ||||||||
| description | This term was created for, but is not limited in use to, Exact Sciences' Cologuard DNA screening test for colorectal cancer. The Cologuard algorithm includes two laboratory procedures performed on a single stool specimen: 1) detection and quantification of fecal occult blood using ELISA; and 2) detection of multiple genetic biomarkers (NDRG4 and BMP3 methylation targets, seven KRAS point mutations, and beta actin as a proxy for the total amount of human DNA in each sample) using magnetic bead based oligonucleotide hybrid capture to isolate the biomarkers followed by quantitative real-time target and signal amplification. The occult blood and genetic biomarker results are subsequently entered into a logistic regression model, and the results from this model are used to calculate a composite score from which the final binary result (positive, negative) is determined. [PMID: 24645800] | ||||||||
| status | ACTIVE | ||||||||
Fully-Specified Name | |||||||||
| component | Noninvasive colorectal cancer DNA+occult blood screening | ||||||||
| property | PrThr = Present or threshold: The Property PrThr stands for “Presence or Threshold”, meaning either a) the actual presence or absence of an analyte, or b) that the amount of analyte detected is over some predetermined threshold. | ||||||||
| time | Pt = Point in time: To identify measures at a point in time. This is a synonym for “spot” or “random” as applied to urine measurements. | ||||||||
| system | Stool = Stool = Fecal | ||||||||
| scale | Ord = Ordinal: Ordered categorical responses, e.g., 1+, 2+, 3+; positive, negative; reactive, indeterminate, nonreactive. | ||||||||
| method | |||||||||
Additional Names | |||||||||
| short name | Noninv colon ca DNA+occ bld scrn Stl Ql | ||||||||
Basic Attributes | |||||||||
| class | MOLPATH | ||||||||
| type | 1 Laboratory | ||||||||
| order vs. observation | Both | ||||||||
Associated Observations | |||||||||
LOINC codes that represent optional associated observation(s) for a clinical observation or laboratory test. A LOINC term may represent a single associated observation or panel containing several associated observations. | |||||||||
Member of these Panels | |||||||||
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History/Usage | |||||||||
| test rank | 2032 of 2000 most commonly performed tests by labs in USA | ||||||||
| first released | |||||||||
| last updated | 2.73 | ||||||||
| last change type | MIN - change to field other than name | ||||||||
| change reason | The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016. | ||||||||
Related Names | |||||||||
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Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.
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