AHA Coding Clinic® for ICD-10-CM and ICD-10-PCS - 2019 Issue 4; New/Revised ICD-10-CM Codes

Adenosine Deaminase Deficiency

Code D81.31, Severe combined immunodeficiency due to adenosine deaminase deficiency, was created for adenosine deaminase (ADA) deficiency that damages the immune system and causes severe combined immunodeficiency (SCID), which is commonly referred to as SCID due to ADA deficiency. ADA is an inherited disorder of purine metabolism that is characterized by the accumulation of deoxyadenosine, a molecule that is toxic to lymphocytes, the cells that make up the immune system. The loss of infection-fighting lymphocytes results in the signs and symptoms of SCID. SCID due to ADA deficiency may present before 6 months of age. The individual experiences...

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