Diseases of White Blood Cells

Effective October 1, 2006, several changes have been made to category 288, Diseases of white blood cells. New codes have been created for different types of neutropenia, hemophagocytic syndromes, decreased white blood cell count and elevated white blood cell count. White blood cells, or leukocytes, play an important role in the body’s immune system by fighting infection. There are several different types of normal white blood cells (WBCs) including neutrophils, lymphocytes, monocytes, eosinophils and basophils. Many different diseases can affect WBC production. Diseases of the white blood cells are primarily classified on the basis of whether...

Subscribe or sign in to view the full article.

Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This premium article reviews a set of October 1, 2006 changes to the white blood cell disease category and explains the broader clinical context for classifying abnormal white blood cell findings. It is aimed at coders and other revenue cycle professionals who need to understand the scope of the revised category, the new subcategories and codes, and the general kinds of documentation or clinical correlation discussed in the update. The article also includes a coding question about neutropenia after chemotherapy and references related diagnosis coding concepts.

Why This Topic Matters

Accurate reporting of white blood cell disorders can depend on the specific type of count abnormality, the underlying cause, and whether the finding is clinically significant. This article helps readers navigate a revision that affects how these conditions are organized and recognized in coding workflows.

Article Sections

  1. Effective date and scope of changes

    Introduces the timing of the update and the broad categories of white blood cell disorders affected by the revision.

  2. Clinical background on white blood cells

    Provides general background on white blood cell function and broad clinical reasons white blood cell production may be reduced or increased.

  3. Documentation and laboratory significance

    Discusses the importance of clinical concurrence and cautions about relying on laboratory findings alone.

  4. ICD-9-CM category 288 revisions

    Outlines the revised white blood cell disease category, including new subcategories and code groups for low and elevated white blood cell counts and related syndromes.

  5. Coding question: neutropenia after chemotherapy

    Presents a brief coding scenario involving neutropenia in the setting of chemotherapy and the related diagnosis coding context.

What You Will Learn

  • How the white blood cell disease category was updated in the 2006 revision
  • Which broad types of white blood cell abnormalities are addressed in the article
  • What clinical documentation considerations are highlighted for these diagnoses
  • How the article frames a chemotherapy-related neutropenia scenario

Who Should Read This

  • Medical coders
  • Coding auditors
  • Revenue cycle staff
  • Clinical documentation specialists
  • Healthcare compliance professionals

Codes Discussed

  • ICD-9-CM: 288
  • ICD-9-CM: 288.0
  • ICD-9-CM: 288.00
  • ICD-9-CM: 288.01
  • ICD-9-CM: 288.02
  • ICD-9-CM: 288.03
  • ICD-9-CM: 288.04
  • ICD-9-CM: 288.09
  • ICD-9-CM: 288.4
  • ICD-9-CM: 288.5
  • ICD-9-CM: 288.50
  • ICD-9-CM: 288.51
  • ICD-9-CM: 288.59
  • ICD-9-CM: 288.6
  • ICD-9-CM: 288.60
  • ICD-9-CM: 288.61
  • ICD-9-CM: 288.62
  • ICD-9-CM: 288.63
  • ICD-9-CM: 288.64
  • ICD-9-CM: 288.65
  • ICD-9-CM: 288.69
  • ICD-9-CM: 288.8
  • ICD-9-CM: 780.6
  • ICD-9-CM: 289.53
  • ICD-9-CM: 075
  • E codes: E933.1

Code Ranges Discussed

  • ICD-9-CM: 288.01-288.09
  • ICD-9-CM: 288.50-288.59
  • ICD-9-CM: 288.60-288.69

Subscribe or sign in to view the full article.

  • The official AHA publication for ICD-10-CM and ICD-10-PCS coding guidelines and advice
  • Current newsletters added each quarter
  • Full Archives - over 3100 articles
  • ALL years/issues back to 1984 organized by year and issue
  • Includes ICD-10-CM/PCS Articles since 2013
  • Fully searchable through Find-A-Code's Comprehensive Search
  • Codes mentioned in articles are linked to Code Information pages
  • Code Information pages link back to related articles
  • View all the articles associated with any code, right from the code page!
Access to this feature is available in the following products:
  • AHA's Coding Clinic® - ICD-10-CM/PCS +Archives

demo
request yours today
subscribe
start today
newsletter
free subscription

Thank you for choosing Find-A-Code, please Sign In to remove ads.

Aimee- AI -powered coding assistant - Try it now for Free Would you like Aimee - AI
to help you with this?