Neuroleptic Malignant Syndrome

The code assignment for neuroleptic malignant syndrome is 333.99 for other extrapyramidal disease. The appropriate code from the E930-E949 series is assigned to identify the adverse effect of a neuroleptic agent, such as E939.1, E939.2, E939.3, or E939.4 (psychotropic agents). If the diagnosis of neuroleptic malignant syndrome is associated with the acute withdrawal of Levodopa therapy for Parkinson's (idiopathic) disease, codes 333.99,332.0, and E936.4 are assigned. The neuroleptic malignant syndrome occurs as a hypersensitivity response in certain patients exposed to neuroleptic agents. It may also be caused by sudden withdrawal...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article discusses neuroleptic malignant syndrome from a coding perspective, with emphasis on how the condition is classified when linked to medication exposure or abrupt withdrawal of therapy. It is intended for coders and other healthcare reimbursement professionals who need to understand the relevant diagnosis and external-cause code categories involved in this topic.

Why This Topic Matters

Neuroleptic malignant syndrome can involve multiple code categories depending on the documented cause, so accurate topic awareness helps support correct record review and code selection.

What You Will Learn

  • How neuroleptic malignant syndrome is discussed in relation to coding classification
  • What broad code categories are associated with medication exposure or therapy withdrawal contexts
  • Which clinical features are mentioned as part of the condition's presentation
  • How the article frames the topic for coding and documentation review

Who Should Read This

  • Medical coders
  • Coding auditors
  • Billing staff
  • Compliance professionals
  • Clinical documentation specialists

Codes Discussed

  • ICD-9-CM: 333.99
  • ICD-9-CM: 332.0
  • ICD-9-CM: E939.1
  • ICD-9-CM: E939.2
  • ICD-9-CM: E939.3
  • ICD-9-CM: E939.4
  • ICD-9-CM: E936.4

Code Ranges Discussed

  • ICD-9-CM: E930-E949

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