AHA Coding Clinic® for ICD-10-CM and ICD-10-PCS - 2024 Issue 4; New/Revised ICD-10-CM Codes

Obesity due to Disruption of Melanocortin 4 (MC4R) Pathway

Code E88.82, Obesity due to disruption of MC4R pathway, was created to specifically identify obesity that is due to disruption of the melanocortin 4 receptor (MC4R) pathway.The MC4R is an autosomal dominantly inherited gene that plays a vital role in regulating food intake, energy homeostasis and body weight, working at the level of the hypothalamus. Affected individuals typically present with early-onset severe obesity and hyperphagia starting within the first year of life, severe hyperinsulinemia, and an increase in lean body mass and bone density due to mutations in genes of the leptin/melanocortin axis.There are a variety...

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