Plasminogen Deficiency

Code E88.02, Plasminogen deficiency, has been created for the rare genetic disorder caused by a deficiency in plasminogen, an inactive proenzyme that circulates in the blood plasma. Plasminogen deficiency is the absence or dysfunction of plasminogen caused by mutations in the PLG gene. There are two types, Type I and type II. Type I plasminogen deficiency, a quantitative deficiency, is also called hypoplasminogenemia. It is associated with inflamed growths caused by an excess in deposits of fibrin, the active enzyme derived from plasminogen that aids in blood clotting and healing of wound tissues. The deposits form ligneous (wood-like)...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article explains plasminogen deficiency as a rare genetic condition, describing its types, clinical presentation, epidemiology, and reported treatment approaches. It is relevant to coders, clinicians, and revenue cycle professionals who need a high-level understanding of the condition’s medical context and its coding assignment in ICD-10-CM.

Why This Topic Matters

Accurate indexing of rare genetic disorders helps support documentation review, diagnosis coding, and search for related clinical and coding guidance. The article also provides context on variable presentation and uncommon manifestations that may affect how the condition is recognized in records.

What You Will Learn

  • What plasminogen deficiency is as a rare inherited disorder
  • How the condition is described in terms of type and symptom patterns
  • Which body sites and clinical presentations are commonly associated with the disorder
  • What is known about occurrence, sex distribution, and reported treatment approaches

Who Should Read This

  • Medical coders
  • Coding auditors
  • Clinicians
  • Revenue cycle staff
  • Health information management professionals

Codes Discussed

  • ICD-10-CM: E88.02

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