Post transfusion purpura (PTP), an uncommon potentially fatal complication, develops within 5 to 10 days following transfusion of blood products and is characterized by the rapid onset of severe thrombocytopenia. The body creates alloantibodies in response to the platelets' antigens present in transfused blood. PTP is caused by antibody mediated destruction of both donor platelets as well as the patient's own platelets and symptoms can include profound thrombocytopenia, purpura and/or hemorrhage. The condition is most common in multiparous women who are sensitized by a human platelet specific alloantigen (HPA) following pregnancy. Intravenous immunoglobulin (IVIg) therapy is the primary treatment. Therapeutic plasma exchange may also be beneficial.
Prior to this change, there was no specific ICD-9-CM diagnosis code to describe PTP.
287 Purpura and other hemorrhagic conditions 287.4 Secondary thrombocytopenia Delete
Posttransfusion purpuraDelete Thrombocytopenia (due to):Delete dilutionalDelete drugsDelete extracorporeal circulation of bloodDelete massive blood transfusionDelete platelet alloimmunizationNew code 287.41 Posttransfusion purpura Posttransfusion purpura from whole blood (fresh) or blood products PTP New code 287.49 Other secondary thrombocytopenia Thrombocytopenia (due to): dilutional drugs extracorporeal circulation of blood massive blood transfusion platelet alloimmunization secondary NOS