Other and Unspecified Adverse Effect of Drug

Effective October 1, 2006, code 995.2, Unspecified adverse effect of drug, medicinal and biological substance has been expanded to provide codes to distinguish between allergic reactions and other adverse effects of drugs. These codes should not be used in the inpatient setting. Their use in the outpatient setting is limited to only those cases where no sign or symptom is documented. If the patient is exhibiting symptoms or signs, the code for that condition should be assigned. An additional code from the E930 through E949 series is also assigned to indicate the responsible drug or biologic substance. 995...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This coding update article covers a revision to the ICD-9-CM adverse-effect category effective October 1, 2006. It is relevant to coders working with drug- and biologic-related adverse effect reporting in both inpatient and outpatient settings, and it discusses the broader documentation context for assigning related diagnosis coding and associated external cause coding.

Why This Topic Matters

Changes to adverse-effect classification can affect diagnosis selection, documentation review, and linkage to the responsible substance. Understanding the update helps coding professionals recognize when the revised category structure applies and what additional coding categories are referenced.

Article Sections

  1. Effective October 1, 2006 update

    Introduces the timing and scope of the ICD-9-CM change to the adverse-effect category. It summarizes the general documentation and setting context discussed in the article.

  2. Revised 995.2 category and new codes

    Outlines the revised diagnosis category and the newly listed subcodes within it. The section presents the updated structure without going into code-specific definitions.

What You Will Learn

  • How a prior adverse-effect category was revised in ICD-9-CM
  • What general documentation context affects selection of the revised category
  • Which broader code group is referenced alongside the diagnosis update
  • How the article organizes the updated code family

Who Should Read This

  • Medical coders
  • Coding auditors
  • Billing staff
  • Compliance professionals
  • Clinical documentation specialists

Codes Discussed

  • ICD-9-CM: 995.2
  • ICD-9-CM: 995.20
  • ICD-9-CM: 995.21
  • ICD-9-CM: 995.22
  • ICD-9-CM: 995.23
  • ICD-9-CM: 995.27
  • ICD-9-CM: 995.29

Code Ranges Discussed

  • ICD-9-CM: E930 through E949

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