Cytogenomic Microarray Analysis for Neoplasia (February 2020)

February 2020 page 10 Cytogenomic Microarray Analysis for Neoplasia For the 2020 Current Procedural Terminology (CPT®) code set, a new Tier 1 molecular pathology procedure code (81277) is available to report genome-wide (cytogenomic) microarray analysis for neoplasia. Prior to 2020, cytogenomic microarray analysis was included as part of Tier 2 code 81406; however, the test has sufficiently increased in utilization to support conversion to Tier 1 status. This article provides an overview of these changes. Tier 1 Molecular Pathology Procedures  81277Cytogenomic neoplasia (genome-wide) microarray analysis, interrogation of genomic regions for copy number and loss-of-heterozygosity variants for chromosomal abnormalities...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article explains a February 2020 CPT update involving cytogenomic microarray analysis for neoplasia. It is aimed at coding professionals, laboratory staff, and clinicians who need to understand the scope of the code-set changes, the relationship between Tier 1 and Tier 2 molecular pathology procedures, and the general clinical context of the service.

Why This Topic Matters

It matters because CPT code-set updates can change how genomic laboratory services are reported and understood across pathology, laboratory medicine, oncology, and revenue cycle workflows.

Article Sections

  1. Tier 1 Molecular Pathology Procedures

    This section discusses the CPT update introducing a new Tier 1 molecular pathology procedure and describes its relationship to an existing Tier 2 code. It also summarizes the accompanying parenthetical guidance at a high level.

  2. Clinical Example and Description of Procedure

    This section presents a typical clinical scenario and outlines the general laboratory workflow associated with the service. It provides context for how the procedure is performed and documented.

What You Will Learn

  • What changed in the 2020 CPT molecular pathology code set for cytogenomic microarray analysis
  • How the article frames the relationship between Tier 1 and Tier 2 molecular pathology procedures
  • What general clinical and laboratory context is associated with this type of neoplasia testing
  • What kinds of CPT guidance accompanied the update

Who Should Read This

  • Medical coders
  • Pathology and laboratory billing staff
  • Genetic testing laboratory professionals
  • Oncology revenue cycle staff
  • Compliance and coding educators

Codes Discussed


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