Reporting pTau and tTau Protein–Testing (84393, 84394) (March 2025)

March 2025 page 13 Reporting pTau and tTau Protein–Testing (84393, 84394) For the CPT 2025 code set, two new codes were established in the Chemistry subsection of the Pathology and Laboratory section to describe testing for phosphorylated Tau (pTau) (84393) for the early detection of diseases such as Alzheimer disease (AD) and testing for total Tau (tTau) (84394) to identify other types of dementia. Before 2025, there were no specific codes available to describe these tests; therefore, the nonspecific immunoassay code 83520, Immunoassay for analyte other than infectious agent antibody or infectious agent antigen; quantitative, not otherwise specified, was...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article explains a 2025 CPT update affecting laboratory chemistry reporting for tau protein testing. It is aimed at coders, billers, laboratory professionals, and clinicians who need to understand the scope of the new guidance, the related clinical context, and the transition from broader pre-2025 reporting practices.

Why This Topic Matters

The article is relevant because it describes new CPT chemistry codes introduced for specialized tau testing used in neurologic and dementia-related evaluation. It helps readers recognize what changed in the code set and why the new specificity matters for laboratory documentation and reporting.

Article Sections

  1. March 2025 page 13

    Publication and page information for the article.

  2. Reporting pTau and tTau Protein–Testing (84393, 84394)

    An introduction to the 2025 CPT chemistry update and the general purpose of the new tau protein testing codes.

  3. Chemistry

    A brief code listing within the chemistry subsection showing the new tau-related entries in context with nearby laboratory codes.

  4. Clinical Examples and Description of Procedure

    Typical neurologic testing scenarios and associated procedural narratives illustrating how the new tau protein tests are presented in practice.

What You Will Learn

  • Why new tau protein testing codes were added to CPT 2025
  • How the article frames the clinical and laboratory context for tau testing
  • What general types of prior reporting were used before the new codes existed
  • How the article presents example scenarios and procedural narratives for the tests

Who Should Read This

  • Medical coders
  • Billing staff
  • Laboratory professionals
  • Clinicians involved in neurologic testing
  • Coding educators

Codes Discussed


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