Can Modifier 22, Unusual Procedural Service, be appended to E/M codes?

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What is the difference between Modifier 21, Prolonged Evaluation and Management Services, and the prolonged (2015)
May modifier 22, Increased Procedural Services, be appended to add-on codes? (2013)
Over the years, the CPT Assistant has listed different timeframes when modifier 22 is appended (2020)
Please provide the definition and illustration of Modifier 21. (2019)
When reporting one E/M service (99213) and one procedure (17000), which code gets the modifier (2015)
In Appendix A of the 2008 CPT codebook, the explanatory language of modifier 25, Significant (2008)

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AMA CPT® Knowledge Base - Jul 31, 2007

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