CPT Knowledgebase - Oct 26, 2017

A patient had a thromboembolic event and was placed on a newer oral anticoagulant (eg, dabigatran, rivaroxaban). The physician wishes to evaluate the patient for venous thrombophilia risk factors. The new oral anticoagulants interfere with these assays and may cause false positive results. Therefore, an in vitro neutralization method is used to eliminate interference to obtain accurate thrombophilia assessments so that the patient does not need to discontinue treatment. Is it appropriate to report code 85525, Heparin neutralization, for assays that eliminate interference from other anticoagulants, as this is the only CPT code to report neutralization, even though the code specifically lists heparin in the code descriptor?

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