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SNOMED CT code SNOMED code 21533003 name Lyase status active date introduced 2002-01-31 fully specified name(s) Substance with lyase mechanism of action (substance) synonyms Substance with lyase mechanism of action Lyase attributes - group0 Has disposition Lyase 736202003 parents Enzyme 90668006 children (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase 130826005 (R)-2-methylmalate dehydratase 74678005 (S)-2-methylmalate dehydratase 77530007 (S)-Norlaudanosoline synthase 89848008 1-aminocyclopropane-1-carboxylate deaminase 25574006 1-aminocyclopropane-1-carboxylate synthase 61489005 16-alpha-hydroxyprogesterone dehydratase 130847009 17alpha-hydroxyprogesterone aldolase 29282000 2,2-dialkylglycine decarboxylase (pyruvate) 23956008 2,3-dimethylmalate lyase 78758004 2-dehydro-3-deoxy-D-pentonate aldolase 5548004 2-dehydro-3-deoxy-L-arabinonate dehydratase 83182008 2-dehydro-3-deoxy-L-pentonate aldolase 51364000 2-dehydro-3-deoxyglucarate aldolase 42832007 2-ethylmalate synthase 72507005 2-hydroxy-3-oxoadipate synthase 3405005 2-hydroxyglutarate synthase 24545008 2-isopropylmalate synthase 16458008 2-methylcitrate dehydratase 15951000 2-methylcitrate synthase 75163007 2-methylisocitrate dehydratase 130848004 2-oxoglutarate decarboxylase 130811008 2-oxopent-4-enoate hydratase 49733006 3-aminobutyryl-CoA ammonia-lyase 130856001 3-chloro-D-alanine dehydrochlorinase 41612005 3-cyanoalanine hydratase 70750005 3-dehydroquinate dehydratase 42465006 3-dehydroquinate synthase 18290005 3-deoxy-D-manno-octulosonate aldolase 45622007 3-ethylmalate synthase 78637000 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase 75849003 3-hydroxy-3-isohexenylglutaryl-CoA lyase 21999008 3-hydroxyaspartate aldolase 69654001 3-hydroxybutyryl-CoA dehydratase 70161007 3-hydroxydecanoyl-[acyl-carrier-protein]-dehydratase 18421002 3-hydroxyoctanoyl-[acyl-carrier-protein]-dehydratase 69995001 3-hydroxypalmitoyl-[acyl-carrier-protein]-dehydratase 22880000 3-isopropylmalate dehydratase 87882007 3-ketovalidoxylamine C-N-lyase 130860003 3-oxolaurate decarboxylase 25926002 3-propylmalate synthase 7056008 4,5-dihydroxyphthalate decarboxylase 56774003 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase 130819005 4-carboxymuconolactone decarboxylase 17900007 4-hydroxy-2-oxoglutarate aldolase 87625009 4-hydroxy-4-methyl-2-oxoglutarate aldolase 67594004 4-hydroxybenzoate decarboxylase 8705006 4-oxalmesaconate hydratase 130832000 4-oxalocrotonate decarboxylase 130817007 4a-hydroxytetrahydrobiopterin dehydratase 130845001 5-dehydro-4-deoxyglucarate dehydratase 69513001 5-guanidino-2-oxopentanoate decarboxylase 130815004 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase 22403009 5alpha-hydroxysteroid dehydratase 71730000 6-methylsalicylate decarboxylase 31876004 6-phospho 2-dehydro-3-deoxygalactonate aldolase 50550009 Acetoacetate decarboxylase 19023004 Acetoin--ribose-5-phosphate transaldolase 130190007 Acetolactate decarboxylase 89203004 Acetolactate synthase 49354001 Acetone-cyanohydrin lyase 130822007 Acetylenecarboxylate hydratase 20371000 Acetylenedicarboxylate hydratase 53468009 Aconitate decarboxylase 112056001 Aconitate hydratase 54239002 Adenosylmethionine decarboxylase 974001 Adenylate cyclase 4105008 Adenylosuccinate lyase 41613000 Aldehyde-lyase 130934000 Aldolase 28598003 Alginate lyase 33844004 Alkylmercury lyase 82671008 Alliin lyase 26304004 Altronate dehydratase 12823004 Aminobenzoate decarboxylase 90047006 Aminocarboxymuconate-semialdehyde decarboxylase 43839009 Aminodeoxygluconate dehydratase 88555009 Ammonia-lyase 130939005 Anthranilate synthase 56455005 Arabinonate dehydratase 41568007 Arginine decarboxylase 4561009 Argininosuccinate lyase 74564004 Aromatic-L-amino-acid decarboxylase 41830001 Arylmalonate decarboxylase 130816003 Aspartate 1-decarboxylase 15769004 Aspartate 4-decarboxylase 72812001 Aspartate ammonia-lyase 81357007 ATP citrate (pro-3S)-lyase 15297009 ATP-dependent H(4)NAD(P)OH dehydratase 130842003 Benzoin aldolase 130823002 Benzoyl formate decarboxylase 34864003 Beta-(9-cytokinin)-alanine synthase 69504003 Beta-alanyl-CoA ammonia-lyase 81880008 Branched-chain-2-oxoacid decarboxylase 130812001 Carbamoyl-serine ammonia-lyase 87039005 Carbon-carbon lyase 130933006 Carbon-halide lyase 130941006 Carbon-nitrogen lyase 130938002 Carbon-oxygen lyase 130936003 Carbon-sulfur lyase 130940007 Carboxycyclohexadienyl dehydratase 130840006 Carboxymethyloxysuccinate lyase 49846006 Carnitine decarboxylase 74145002 CDPglucose 4,6-dehydratase 68657000 Chondroitin ABC lyase 24352006 Chondroitin AC lyase 61630008 Chorismate synthase 22224001 Citramalate lyase 24791003 Citramalyl-CoA lyase 424006 Citrate (re)-synthase 82786006 Citrate dehydratase 36848008 Citrate(pro-3S)-lyase 33417004 Citrate(si)-synthase 87222001 Citryl-CoA lyase 89453007 Crotonobetainyl-CoA hydratase 785897001 Crotonoyl-[acyl-carrier-protein] hydratase 78400000 Cyanamide hydratase 10914009 Cyanate hydrolase 83342006 Cyanate lyase 130862006 removed: 2007-01-31 Cyanide hydratase 14388000 Cystathionine beta-lyase 34757005 Cystathionine beta-synthase 51256009 Cystathionine gamma-lyase 32245004 Cysteine lyase 60500000 Cysteine-conjugate beta-lyase 60762008 D(-)-tartrate dehydratase 130830008 D-fuconate dehydratase 5991002 D-glutamate cyclase 27412001 D-serine ammonia-lyase 52358009 DDT-dehydrochlorinase 26841005 Decarboxylase 130932001 Decylcitrate synthase 77037001 Decylhomocitrate synthase 82989006 Dehydro-L-gulonate decarboxylase 61573005 Deoxyribodipyrimidine photo-lyase 37023004 Deoxyribose-phosphate aldolase 30158003 Diaminopimelate decarboxylase 20478005 Diaminopropionate ammonia-lyase 130857005 Dihydrodipicolinate synthase 82623008 Dihydroneopterin aldolase 51248006 Dihydroxy-acid dehydratase 13597005 Dihydroxyfumarate decarboxylase 57827006 Dihydroxyphenylalanine ammonia-lyase 87236006 Dimethylaniline-N-oxide aldolase 14539004 Dimethylmaleate hydratase 130834004 Dimethylpropiothetin dethiomethylase 70276009 Diphosphomevalonate decarboxylase 58014006 DNA-(apurinic or apyrimidinic site) lyase 130855002 dTDPglucose 4,6 dehydratase 46066002 Enolase 25089008 Enoyl-CoA hydratase 87504000 erythro-3-Hydroxyaspartate dehydratase 80992003 Ethanolamine ammonia-lyase 71391002 Ethanolamine-phosphate phospho-lyase 57679009 Exo-(1,4)-alpha-D-glucan lyase 130851006 Exopolygalacturonate lyase 2883002 Ferrochelatase 57960008 Formiminotetrahydrofolate cyclodeaminase 10160005 Fructose-6-phosphate phosphoketolase 13634007 Fucosterol-epoxide lyase 130818002 Fumarate hydratase 304284008 Galactarate dehydratase 13293005 Galactonate dehydratase 7237008 Gallate decarboxylase 13739008 GDPmannose 4,6 dehydratase 46407003 Gentisate decarboxylase 9302003 Glucarate dehydratase 21456009 Gluconate dehydratase 30805006 Glucosaminate ammonia-lyase 52881004 Glutaconyl-CoA decarboxylase 130810009 Glutamate decarboxylase 41465008 Glutamate decarboxylase 65 116741003 Glycerol dehydratase 57542003 Guanylate cyclase 28954008 Heparin lyase 50358001 Heparitin-sulfate lyase 49508006 Histidine ammonia-lyase 24185006 Histidine decarboxylase 35131008 Homoaconitate hydratase 27961009 Homocitrate synthase 57452002 Homocysteine desulfhydrase 35415009 Hyaluronate lyase 19142003 Hydrolyase 130937007 Hydroperoxide dehydratase 130841005 Hydroxyglutamate decarboxylase 75725009 Hydroxymandelonitrile lyase 89781000 Hydroxymethylglutaryl-CoA lyase 709558005 Hydroxymethylglutaryl-CoA lyase 82129008 removed: 2007-01-31 Hydroxymethylglutaryl-CoA synthase 66037006 Hydroxynitrilase 130824008 Hydroxypyruvate decarboxylase 18395003 Imidazoleglycerol-phosphate dehydratase 43117009 Indole-3-glycerol-phosphate synthase 17628004 Indoleacetaldoxime dehydratase 52326004 Indolepyruvate decarboxylase 130814000 Isocitrate lyase 61643008 Isohexenylglutaconyl-CoA hydratase 51880001 Itaconyl-CoA hydratase 87033006 Ketopantoaldolase 80832000 Ketotetrose-phosphate aldolase 61730004 Kievitone hydratase 130844002 L-3-cyanoalanine synthase 73586008 L-arabinonate dehydratase 17598004 L-fuconate dehydratase 59267008 L-fuculose-phosphate aldolase 74085005 L-rhamnonate dehydratase 130839009 L-serine ammonia-lyase 17626000 Lactate aldolase 130821000 Lactoyl-CoA dehydratase 63307000 Lactoylglutathione lyase 17676003 Long-chain-enoyl-CoA hydratase 4153007 Lysine decarboxylase 79328003 Malate synthase 36098005 Maleate hydratase 35181004 Malonate-semialdehyde dehydratase 2179004 Malonyl-CoA decarboxylase 15092006 Malyl-CoA lyase 66103001 Mandelonitrile lyase 31403000 removed: 2007-07-31 Mannonate dehydratase 112057005 Methionine decarboxylase 63527000 Methionine gamma-lyase 85609000 Methylaspartate ammonia-lyase 44207004 Methylglyoxal synthase 20211008 Methylisocitrate lyase 57091004 myo-Inosose-2 dehydratase 45065009 N-Acetylneuraminate lyase 13541007 N-Acetylneuraminate synthase 32165004 N-Acylneuraminate-9-phosphate synthase 59718005 Nitrile hydratase 130833005 O-Acetylhomoserine (thiol)-lyase 77932005 O-Acetylserine (thiol)-lyase 50195007 o-Pyrocatechuate decarboxylase 87981001 O-Succinyl homoserine (thiol)-lyase 54774000 Octadecanal decarbonylase 130828006 Octopamine dehydratase 130836002 Oleate hydratase 8982000 Oligogalacturonide lyase 28767002 Ornithine cyclodeaminase 35808006 Ornithine decarboxylase 32302009 Orotidine-5'-phosphate decarboxylase 61243000 Orsellinate decarboxylase 64527009 Oxalate decarboxylase 48945000 Oxaloacetate decarboxylase 3982003 Oxalomalate lyase 86813000 Oxalyl-CoA decarboxylase 90066006 Oxo-acid-lyase 130935004 Pantothenoylcysteine decarboxylase 43097007 Pectate lyase 28752001 Pectin lyase 31052008 Pegvaliase 770965008 Peptidylamidoglycolate lyase 130859008 Phaseollidin hydratase 130846000 Phenylalanine ammonia-lyase 74014003 Phenylalanine decarboxylase 36677006 Phenylpyruvate decarboxylase 25589002 Phenylserine aldolase 2208001 Phosphatidylserine decarboxylase 53368005 Phospho-2-dehydro-3-deoxygluconate aldolase 83770005 Phospho-2-dehydro-3-deoxyheptonate aldolase 52398006 Phospho-2-dehydro-3-deoxyoctonate aldolase 34003008 Phospho-5-dehydro-2-deoxygluconate aldolase 14586000 Phosphoenolpyruvate carboxykinase (ATP) 11643006 Phosphoenolpyruvate carboxykinase (GTP) 67412002 Phosphoenolpyruvate carboxykinase (pyrophosphate) 58187009 Phosphoenolpyruvate carboxylase 81969007 Phosphogluconate dehydratase 37970000 Phosphoketolase 28549007 Phosphopantothenoylcysteine decarboxylase 22987003 Phosphoribosylaminoimidazole carboxylase 70032009 Phosphorus-oxygen lyase 130942004 Poly(alpha-L-guluronate) lyase 130849007 Porphobilinogen synthase 15612008 Prephenate dehydratase 42130002 Propanediol dehydratase 49686000 Protoaphin-aglucone dehydratase (cyclizing) 3844007 Protocatechuate decarboxylase 21410001 Pseudouridylate synthase 35467008 Purine imidazole-ring cyclase 130858000 Pyrazolylalanine synthase 14439001 Pyruvate decarboxylase 44556002 Rhamnulose-1-phosphate aldolase 24517002 Riboflavinase 86054009 Ribulose-bisphosphate carboxylase 76560006 S-Alkylcysteine lyase 35296006 Scytalone dehydratase 130843008 Serine-sulfate ammonia-lyase 60722009 Sphinganine-1-phosphate aldolase 13780001 Stipitatonate decarboxylase 39223004 Sulfinoalanine decarboxylase 27370002 Sulfoacetaldehyde lyase 19013008 Synephrine dehydratase 130837006 Tagatose-bisphosphate aldolase 130825009 Tartrate decarboxylase 130813006 Tartrate dehydratase 2719002 Tartronate-semialdehyde synthase 81537009 Threonine aldolase 79987001 removed: 2007-01-31 Threonine dehydratase 69180004 Threonine synthase 26387009 trans-L-3-Hydroxyproline dehydratase 79545007 Trimethylamine-oxide aldolase 18732001 Tryptophan synthase 70213008 Tryptophanase 9986007 Tyrosine phenol-lyase 46845009 UDP glucose 4,6-dehydratase 49529002 UDPgalacturonate decarboxylase 25175000 UDPglucuronate decarboxylase 70608003 Uracil-5-carboxylate decarboxylase 8168004 Ureidoglycolate lyase 112058000 Urocanate hydratase 13295003 Uroporphyrinogen-III synthase 39765006 Valine decarboxylase 70367000 Xanthan lyase 130850007 Xylonate dehydratase 130831007 hierarchies a selection of possible paths
SNOMED CT Concept 138875005 105590001 766739005 90668006 21533003 ancestors sorted most to least specific
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