CPT® Code Modifiers

-/+ Deleted, Replaced, Expanded Codes

section notes

Genetic Testing Code Modifiers

section notes

Neoplasia (Lymphoid/Hematopoietic)

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2A   RUNX1 or CBFA2T1, commonly called AML1 or ETO, genes associated with t(8;21)
2B   BCR or ABL1, genes associated with t(9;22) (chronic myelogenous or acute leukemia) BCR - also ABL
2C    PBX1 or TCF3, genes associated with t(1;19) (acute lymphoblastic leukemia) CGF1
2D   CBFB or MYH11, genes associated with inv 16 (acute myelogenous leukemia) CBF beta (leukemia)
2E   MLL (acute leukemia)
2F    PML or RARA, genes associated with t(15;17) (acute promyelocytic leukemia) PML/RAR alpha
2G   ETV6, commonly called TEL, gene associated with t(12;21) (acute leukemia) TEL (Leukemia)
2H   BCL2 (B cell lymphoma, follicle center cell origin) bcl-2 (Lymphoma)
2I   CCND1, commonly called BCL1, cyclin D1 (Mantle cell lymphoma, myeloma) bcl-1 (lymphoma)
2J   MYC (Burkitt lymphoma) c-myc (lymphoma)
2K   IgH (lymphoma/leukemia)
2L   IGK (lymphoma/leukemia)
2M   TRB, T cell receptor beta (lymphoma/leukemia)
2N   TRG, T cell receptor gamma (lymphoma/leukemia)
2O   SIL or TAL1 (T cell leukemia)
2Q   API1 or MALT1 (MALT lymphoma)
2R   NPM or ALK, genes associated with t(2;5) (anaplastic large cell lymphoma)
2S   FLT3 (Acute myelogenous leukemia)
2T   BCL6 (B cell lymphoma)
2Z    Lymphoid/hematopoietic neoplasia, not otherwise specified
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