AHA Coding Clinic® for ICD-10-CM and ICD-10-PCS - 2026 Issue 1; Section X – New Technology
CPI-601 Enzyme Replacement Therapy
In table XW0, Introduction of Anatomical Regions, substance value 2 CPI-601 Enzyme Replacement Therapy, and body part value 6 Cerebral Ventricle, were added to approach value 3 Percutaneous, to capture CPI-601 enzyme therapy when infused to treat infantile Batten disease, caused by mutations in various CLN genes. CPI-601 infusion replaces the recombinant human palmitoyl-protein thioesterase-1 (rhPPT1) enzyme.Body Part Approach Device/Substance/Technology Qualifier 6 Cerebral Ventricle 3 Percutaneous 2 CPI-601 Enzyme Replacement Therapy B New Technology Group 11 ...
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Article Overview
This article covers a focused medical coding update in ICD-10-PCS related to an enzyme replacement therapy infusion procedure. It is relevant to inpatient coders, CDI staff, and coding educators who track procedure table changes and technology-specific updates. The article provides the context for the update, the affected anatomical site and approach, and the associated new technology grouping.
Why This Topic Matters
This update may affect how a specific procedure is captured in facility coding systems and how coders identify the proper procedure table elements for documentation involving this therapy.
What You Will Learn
- The general purpose of the coding update
- Which procedure table elements were added or updated
- The clinical context for the therapy addressed in the article
- How the article frames the technology grouping associated with the update
Who Should Read This
- Inpatient coders
- Coding auditors
- Clinical documentation integrity specialists
- Coding educators
- Revenue cycle staff
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