AHA Coding Clinic® for ICD-10-CM and ICD-10-PCS - 2026 Issue 1; Section X – New Technology

CPI-601 Enzyme Replacement Therapy

In table XW0, Introduction of Anatomical Regions, substance value 2 CPI-601 Enzyme Replacement Therapy, and body part value 6 Cerebral Ventricle, were added to approach value 3 Percutaneous, to capture CPI-601 enzyme therapy when infused to treat infantile Batten disease, caused by mutations in various CLN genes. CPI-601 infusion replaces the recombinant human palmitoyl-protein thioesterase-1 (rhPPT1) enzyme.Body Part Approach Device/Substance/Technology Qualifier 6 Cerebral Ventricle 3 Percutaneous 2 CPI-601 Enzyme Replacement Therapy B New Technology Group 11 ...

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