AHA Coding Clinic® for ICD-10-CM and ICD-10-PCS - 2026 Quarter 4; ICD-10-PCS New/Revised Codes Section 3 – Administration

Enzymatic/Chemical Agent Debridement

In table 3E0, Introduction in Physiological Systems and Anatomical Regions, qualifier value F Other Enzymatic/Chemical Agent, was added to body system values 0 Skin and Mucous Membranes, and 1 Subcutaneous Tissue, substance value G Other Therapeutic Substance, and approach value X External. This addition will capture the use of topical enzymatic agents for wounds. Body System/Region Approach Substance Qualifier 0 Skin and Mucous Membranes 1 Subcutaneous Tissue X External G Other Therapeutic Substance F Other Enzymatic/Chemical Agent For example, Collagenase SANTYL Ointment and NexoBrid® (anacaulase-bcdb) Gel are enzymatic agents that are used to dissolve nonviable necrotic tissue. Clostridial collagenase...

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