AHA Coding Clinic® for ICD-10-CM and ICD-10-PCS - 2025 Issue 4; ICD-10-PCS New/Revised Codes Section X—New Technology
Gene Expression Testing System for Whole Blood Samples
In table XXE, Measurement of Physiological Systems, technology value B Infection and Immune Response, Gene Expression Testing System, was added to the body part value 5 Circulatory, to capture a gene expression testing system for whole blood samples.Body Part Approach Device/Substance/Technology Qualifier 5 Circulatory X External B Infection and Immune Response, Gene Expression Testing System B New Technology Group 11 For example, the TriVerity™ test measures 29 host response mRNA genes to score the likelihood of bacterial infection, viral infection, and the severity of illness. The test is performed on patients suspected of an acute infection with one...
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Article Overview
This article covers a table update in ICD-10-PCS Measurement of Physiological Systems that adds a gene expression testing system for whole blood samples. It is useful for coding professionals, CDI teams, and reimbursement staff who track procedure code structure changes, technology assignments, and related clinical testing context. The article also references an example test used in acute infection and sepsis evaluation to illustrate the type of service involved.
Why This Topic Matters
Updates to ICD-10-PCS technology values affect how procedure reporting is structured and interpreted. Readers working in inpatient coding, HIM, and clinical documentation need to understand the scope of the change and the clinical setting it supports.
Article Sections
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ICD-10-PCS table update
Describes a change in the Measurement of Physiological Systems table and the addition of a new technology value related to gene expression testing for whole blood samples.
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Clinical example
Provides an example of a whole blood gene expression test and summarizes the general clinical context in which such testing may be performed.
What You Will Learn
- How the article relates to an ICD-10-PCS table update
- What general type of technology was added to the procedure classification structure
- How the article frames the clinical context for whole blood gene expression testing
- Why this update may matter to inpatient coding and documentation review
Who Should Read This
- Inpatient coders
- HIM professionals
- Clinical documentation improvement specialists
- Compliance staff
- Revenue cycle professionals
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